ENSDARG00000018643


Danio rerio

Features
Gene ID: ENSDARG00000018643
  
Biological name :igf2a
  
Synonyms : igf2a / insulin-like growth factor 2a
  
Possible biological names infered from orthology : IGF2 / insulin like growth factor 2 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344 / P09535
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 48870496
Gene end: 48876480
  
Corresponding Affymetrix probe sets: Dr.8145.1.S1_at (Zebrafish Array)   NM_131433_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000016954
NCBI entrez gene - 30710     See in Manteia.
RefSeq - NM_131433
RefSeq Peptide - NP_571508
swissprot - Q5U3B4
ZFIN ID - ZDB-GENE-991111-3
Ensembl - ENSDARG00000018643
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGF2ENSGALG00000035282Gallus gallus
 IGF2ENSG00000167244Homo sapiens
 Igf2ENSMUSG00000048583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
igf2b / insulin-like growth factor 2b / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*ENSDARG0000003330750
igf1 / insulin-like growth factor 1 / P05017* / P05019* / Insulin-like growth factor I *ENSDARG0000009413227
igf3 / insulin-like growth factor 3ENSDARG0000005805823


Protein motifs (from Interpro)
Interpro ID Name
 IPR013576  Insulin-like growth factor II E-peptide, C-terminal
 IPR016179  Insulin-like
 IPR022334  Insulin-like growth factor II
 IPR022350  Insulin-like growth factor
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030903 notochord development IMP
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IDA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood decreased fluid flow , abnormal
Show

 ZFA:0000008 brain brain structure , abnormal
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 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm distended , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart increased size , abnormal
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 ZFA:0000131 neural keel neural keel apoptotic , abnormal
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 ZFA:0000135 notochord notochord undulate , abnormal
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 ZFA:0000155 somite somite shape , abnormal
somite morphology , abnormal
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 ZFA:0000173 bulbus arteriosus bulbus arteriosus morphology , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism wholly ventralized , abnormal
whole organism curved ventral , abnormal
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 ZFA:0001115 trunk trunk has fewer parts of type somite , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased size , abnormal
intersegmental vessel disorganized , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature increased accumulation blood , abnormal
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 ZFA:0005034 parachordal vessel parachordal vessel morphology , abnormal
parachordal vessel hypoplastic , abnormal
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 ZFA:0005037 post-vent vasculature post-vent vasculature increased accumulation blood , abnormal
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 ZFA:0005249 vasculature vasculature increased accumulation blood , abnormal
vasculature disorganized , abnormal
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 ZFA:0005297 cranial blood vessel cranial blood vessel decreased size , abnormal
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 ZFA:0007028 spinal cord neural keel spinal cord neural keel apoptotic , abnormal
Show

 ZFA:0007057 ocular blood vessel ocular blood vessel decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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