ENSGALG00000035282


Gallus gallus

Features
Gene ID: ENSGALG00000035282
  
Biological name :IGF2
  
Synonyms : IGF2 / Insulin-like growth factor II / P33717
  
Possible biological names infered from orthology : insulin like growth factor 2 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344 / P09535
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 13774857
Gene end: 13783200
  
Corresponding Affymetrix probe sets: Gga.10702.1.A1_at (Chicken Array)   Gga.10702.1.S1_at (Chicken Array)   Gga.8511.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048743
NCBI entrez gene - 395097     See in Manteia.
RefSeq - NM_001030342
RefSeq - XM_015286525
RefSeq Peptide - NP_001025513
swissprot - P33717
Ensembl - ENSGALG00000035282
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igf2aENSDARG00000018643Danio rerio
 igf2bENSDARG00000033307Danio rerio
 IGF2ENSG00000167244Homo sapiens
 Igf2ENSMUSG00000048583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGF-I / P18254 / Insulin-like growth factor I / IGF1* / P05017* / P05019* / insulin like growth factor 1*ENSGALG0000001275529


Protein motifs (from Interpro)
Interpro ID Name
 IPR013576  Insulin-like growth factor II E-peptide, C-terminal
 IPR016179  Insulin-like
 IPR022334  Insulin-like growth factor II
 IPR022350  Insulin-like growth factor
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031017 exocrine pancreas development IEA
 biological_processGO:0031056 regulation of histone modification IEA
 biological_processGO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0051147 regulation of muscle cell differentiation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060669 embryonic placenta morphogenesis IEA
 biological_processGO:2000467 positive regulation of glycogen (starch) synthase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004293 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction
 ENSGALG00000003580 MMP2 / Q90611 / 72 kDa type IV collagenase / P08253* / P33434* / matrix metallopeptidase 2* / 72 kDa type IV collagenase PEX*  / reaction
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSGALG00000019061 MMP1* / MMP8* / Mmp1b* / Mmp1a* / P22894* / P03956* / O70138* / Neutrophil collagenase * / matrix metallopeptidase 1* / matrix metallopeptidase 8* / interstitial collagenase A preproprotein *  / reaction
 ENSGALG00000040651 IGF1R / insulin-like growth factor 1 receptor precursor / P08069* / insulin like growth factor 1 receptor*  / complex / reaction
 ENSGALG00000037940 IGFBP3 / insulin like growth factor binding protein 3 / P17936* / P47878*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000028886 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction
 ENSGALG00000011468 IGFBP5 / insulin like growth factor binding protein 5 / P24593* / Q07079*  / reaction / complex






 

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