ENSGALG00000040651


Gallus gallus

Features
Gene ID: ENSGALG00000040651
  
Biological name :IGF1R
  
Synonyms : IGF1R / insulin-like growth factor 1 receptor precursor
  
Possible biological names infered from orthology : insulin like growth factor 1 receptor / P08069
  
Species: Gallus gallus
  
Chr. number: 10
Strand: -1
Band:
Gene start: 16697772
Gene end: 16838212
  
Corresponding Affymetrix probe sets: Gga.2182.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000056946
NCBI entrez gene - 395889     See in Manteia.
RefSeq - NM_205032
RefSeq Peptide - NP_990363
swissprot - A0A1D5PVH7
Ensembl - ENSGALG00000040651
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igf1raENSDARG00000027423Danio rerio
 igf1rbENSDARG00000034434Danio rerio
 IGF1RENSG00000140443Homo sapiens
 Igf1rENSMUSG00000005533Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INSR / insulin receptor / P06213* / P15208* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSGALG0000004075861
INSRR / insulin receptor related receptor / P14616* / Q9WTL4* / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain*ENSGALG0000001325357
ROS1 / ROS proto-oncogene 1, receptor tyrosine kinase / P08922* / Q78DX7* / Proto-onco tyrosine-protein kinase ROS *ENSGALG0000001491320
LTK / leukocyte receptor tyrosine kinase / P08923* / P29376* / Leukocyte tyrosine kinase receptor *ENSGALG0000000861517
NTRK3 / Q91044 / NT-3 growth factor receptor / Q16288* / Q6VNS1* / neurotrophic receptor tyrosine kinase 3*ENSGALG0000004024115
NTRK2 / Q91987 / BDNF/NT-3 growth factors receptor / P15209* / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSGALG0000001259415
NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *ENSGALG0000001901914
MUSK / muscle, skeletal receptor tyrosine protein kinase precursor / O15146* / Q61006* / muscle associated receptor tyrosine kinase* / Muscle, skeletal receptor tyrosine-protein kinase *ENSGALG0000001572814
DDR2 / discoidin domain receptor tyrosine kinase 2 / Q16832* / Q62371* / Discoidin domain-containing receptor 2 *ENSGALG0000003932213
ROR2 / receptor tyrosine kinase like orphan receptor 2 / Q01974* / Q9Z138*ENSGALG0000001520813
ROR1 / receptor tyrosine kinase like orphan receptor 1 / Q01973* / Q9Z139* / Inactive tyrosine-protein kinase transmembrane receptor ROR1 *ENSGALG0000001101913
DDR1 / Q03146* / Q08345* / discoidin domain receptor tyrosine kinase 1* / Epithelial discoidin domain-containing receptor 1 *ENSGALG0000000861613
PTK7 / inactive tyrosine-protein kinase 7 precursor / Q8BKG3* / Q13308* / Inactive tyrosine-protein kinase 7 * / protein tyrosine kinase 7 (inactive)*ENSGALG0000000860911
ALK* / P97793* / Q9UM73* / ALK receptor tyrosine kinase* / ALK tyrosine kinase receptor *ENSGALG0000000903410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003961  Fibronectin type III
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016246  Tyrosine-protein kinase, insulin-like receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0051389 inactivation of MAPKK activity IEA
 biological_processGO:0097242 amyloid-beta clearance IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005010 insulin-like growth factor-activated receptor activity IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0043559 insulin binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000012755 IGF-I / P18254 / Insulin-like growth factor I / IGF1* / P05017* / P05019* / insulin like growth factor 1*  / reaction / complex
 ENSGALG00000035282 IGF2 / P33717 / Insulin-like growth factor II / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / reaction / complex
 ENSGALG00000040651 IGF1R / insulin-like growth factor 1 receptor precursor / P08069* / insulin like growth factor 1 receptor*  / complex






 

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