ENSGALG00000012755


Gallus gallus

Features
Gene ID: ENSGALG00000012755
  
Biological name :IGF-I
  
Synonyms : IGF-I / Insulin-like growth factor I / P18254
  
Possible biological names infered from orthology : IGF1 / insulin like growth factor 1 / P05017 / P05019
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 55335204
Gene end: 55383631
  
Corresponding Affymetrix probe sets: Gga.850.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020787
NCBI entrez gene - 418090     See in Manteia.
RefSeq - NM_001004384
RefSeq Peptide - NP_001004384
swissprot - C5J073
swissprot - P18254
Ensembl - ENSGALG00000012755
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igf1ENSDARG00000094132Danio rerio
 IGF1ENSG00000017427Homo sapiens
 Igf1ENSMUSG00000020053Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGF2 / P33717 / Insulin-like growth factor II / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*ENSGALG0000003528236


Protein motifs (from Interpro)
Interpro ID Name
 IPR016179  Insulin-like
 IPR022341  Insulin-like growth factor I
 IPR022350  Insulin-like growth factor
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001775 cell activation IEA
 biological_processGO:0007405 neuroblast proliferation IMP
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0010467 gene expression IDA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010560 positive regulation of glycoprotein biosynthetic process IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
 biological_processGO:0014896 muscle hypertrophy IEA
 biological_processGO:0014904 myotube cell development IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0021650 vestibulocochlear nerve formation IMP
 biological_processGO:0030166 proteoglycan biosynthetic process IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0035630 bone mineralization involved in bone maturation IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0045445 myoblast differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045821 positive regulation of glycolytic process IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0046676 negative regulation of insulin secretion IDA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051450 myoblast proliferation IEA
 biological_processGO:0060283 negative regulation of oocyte development IEA
 biological_processGO:0061051 positive regulation of cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0061560 cranial ganglion formation IMP
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IEA
 biological_processGO:0090103 cochlea morphogenesis IMP
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria ISS
 biological_processGO:0090277 positive regulation of peptide hormone secretion IDA
 biological_processGO:1904075 positive regulation of trophectodermal cell proliferation IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1905460 negative regulation of vascular associated smooth muscle cell apoptotic process IEA
 biological_processGO:1990418 response to insulin-like growth factor stimulus IDA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex IEA
 cellular_componentGO:0042567 insulin-like growth factor ternary complex IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004293 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction
 ENSGALG00000003580 MMP2 / Q90611 / 72 kDa type IV collagenase / P08253* / P33434* / matrix metallopeptidase 2* / 72 kDa type IV collagenase PEX*  / reaction
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSGALG00000037940 IGFBP3 / insulin like growth factor binding protein 3 / P17936* / P47878*  / complex / reaction
 ENSGALG00000040651 IGF1R / insulin-like growth factor 1 receptor precursor / P08069* / insulin like growth factor 1 receptor*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000019061 MMP1* / MMP8* / Mmp1b* / Mmp1a* / P22894* / P03956* / O70138* / Neutrophil collagenase * / matrix metallopeptidase 1* / matrix metallopeptidase 8* / interstitial collagenase A preproprotein *  / reaction
 ENSGALG00000028886 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction
 ENSGALG00000011468 IGFBP5 / insulin like growth factor binding protein 5 / P24593* / Q07079*  / reaction / complex






 

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