ENSGALG00000011468


Gallus gallus

Features
Gene ID: ENSGALG00000011468
  
Biological name :IGFBP5
  
Synonyms : IGFBP5 / insulin like growth factor binding protein 5
  
Possible biological names infered from orthology : P24593 / Q07079
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 23359550
Gene end: 23376226
  
Corresponding Affymetrix probe sets: Gga.9364.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037370
NCBI entrez gene - 424220     See in Manteia.
RefSeq - XM_422069
swissprot - F1ND88
Ensembl - ENSGALG00000011468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp5aENSDARG00000039264Danio rerio
 igfbp5bENSDARG00000025348Danio rerio
 IGFBP5ENSG00000115461Homo sapiens
 Igfbp5ENSMUSG00000026185Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGFBP3 / insulin like growth factor binding protein 3 / P17936* / P47878*ENSGALG0000003794042
IGFBP4 / insulin-like growth factor-binding protein 4 precursor / P22692* / P47879* / insulin like growth factor binding protein 4*ENSGALG0000004067235
IGFBP1 / insulin-like growth factor-binding protein 1 precursor / P08833* / P47876* / insulin like growth factor binding protein 1*ENSGALG0000004349332
IGFBP2 / insulin-like growth factor-binding protein 2 precursor / P18065* / P47877* / insulin like growth factor binding protein 2*ENSGALG0000001146929


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR012213  Insulin-like growth factor binding protein 5
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043567 regulation of insulin-like growth factor receptor signaling pathway IBA
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0044342 type B pancreatic cell proliferation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045926 negative regulation of growth IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060056 mammary gland involution IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:1901862 negative regulation of muscle tissue development IEA
 biological_processGO:1904205 negative regulation of skeletal muscle hypertrophy IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0042567 insulin-like growth factor ternary complex IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA
 molecular_functionGO:0031995 insulin-like growth factor II binding IBA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000012755 IGF-I / P18254 / Insulin-like growth factor I / IGF1* / P05017* / P05019* / insulin like growth factor 1*  / complex / reaction
 ENSGALG00000035282 IGF2 / P33717 / Insulin-like growth factor II / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr