ENSG00000115461


Homo sapiens

Features
Gene ID: ENSG00000115461
  
Biological name :IGFBP5
  
Synonyms : IGFBP5 / insulin like growth factor binding protein 5 / P24593
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q35
Gene start: 216672105
Gene end: 216695525
  
Corresponding Affymetrix probe sets: 1555997_s_at (Human Genome U133 Plus 2.0 Array)   203424_s_at (Human Genome U133 Plus 2.0 Array)   203425_s_at (Human Genome U133 Plus 2.0 Array)   203426_s_at (Human Genome U133 Plus 2.0 Array)   211958_at (Human Genome U133 Plus 2.0 Array)   211959_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000233813
Ensembl peptide - ENSP00000413474
NCBI entrez gene - 3488     See in Manteia.
OMIM - 146734
RefSeq - NM_000599
RefSeq Peptide - NP_000590
swissprot - C9JXX4
swissprot - A0A024R433
swissprot - P24593
Ensembl - ENSG00000115461
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igfbp5aENSDARG00000039264Danio rerio
 igfbp5bENSDARG00000025348Danio rerio
 IGFBP5ENSGALG00000011468Gallus gallus
 Igfbp5ENSMUSG00000026185Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGFBP3 / P17936 / insulin like growth factor binding protein 3ENSG0000014667444
IGFBP4 / P22692 / insulin like growth factor binding protein 4ENSG0000014175336
IGFBP6 / P24592 / insulin like growth factor binding protein 6ENSG0000016777932
IGFBP2 / P18065 / insulin like growth factor binding protein 2ENSG0000011545731
IGFBP1 / P08833 / insulin like growth factor binding protein 1ENSG0000014667826


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009168  Insulin-like growth factor binding protein
 IPR012213  Insulin-like growth factor binding protein 5
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR022321  Insulin-like growth factor-binding protein family 1-6, chordata
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IDA
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0044342 type B pancreatic cell proliferation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045926 negative regulation of growth IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IDA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060056 mammary gland involution IEA
 biological_processGO:0060416 response to growth hormone ISS
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:1901862 negative regulation of muscle tissue development IEA
 biological_processGO:1904205 negative regulation of skeletal muscle hypertrophy IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0016942 insulin-like growth factor binding protein complex IC
 cellular_componentGO:0042567 insulin-like growth factor ternary complex IDA
 molecular_functionGO:0001968 fibronectin binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IPI
 molecular_functionGO:0031995 insulin-like growth factor II binding IBA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000099769 IGFALS / P35858 / insulin like growth factor binding protein acid labile subunit  / complex / reaction
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / reaction / complex
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / reaction / complex
 ENSG00000182752 PAPPA / Q13219 / pappalysin 1  / reaction
 ENSG00000116183 PAPPA2 / Q9BXP8 / pappalysin 2  / reaction






 

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