ENSG00000116183


Homo sapiens

Features
Gene ID: ENSG00000116183
  
Biological name :PAPPA2
  
Synonyms : PAPPA2 / pappalysin 2 / Q9BXP8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.2
Gene start: 176463171
Gene end: 176845605
  
Corresponding Affymetrix probe sets: 211918_x_at (Human Genome U133 Plus 2.0 Array)   213332_at (Human Genome U133 Plus 2.0 Array)   214689_at (Human Genome U133 Plus 2.0 Array)   228237_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356633
Ensembl peptide - ENSP00000356634
NCBI entrez gene - 60676     See in Manteia.
RefSeq - XM_017002025
RefSeq - NM_020318
RefSeq - NM_021936
RefSeq - XM_011509858
RefSeq - XM_017002023
RefSeq - XM_017002024
RefSeq - XM_005245422
RefSeq - XM_011509857
RefSeq Peptide - NP_068755
RefSeq Peptide - NP_064714
swissprot - Q9BXP8
Ensembl - ENSG00000116183
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pappa2ENSDARG00000076020Danio rerio
 ENSGALG00000040432Gallus gallus
 Pappa2ENSMUSG00000073530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PAPPA / Q13219 / pappalysin 1ENSG0000018275240


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000800  Notch domain
 IPR006558  LamG-like jellyroll fold
 IPR008754  Peptidase M43, pregnancy-associated plasma-A
 IPR011936  Myxococcus cysteine-rich repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR026918  Pappalysin-2
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0009651 response to salt stress IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0060349 bone morphogenesis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular NAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IDA
 molecular_functionGO:0008270 zinc ion binding NAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115461 IGFBP5 / P24593 / insulin like growth factor binding protein 5  / reaction
 ENSG00000141753 IGFBP4 / P22692 / insulin like growth factor binding protein 4  / reaction
 ENSG00000099769 IGFALS / P35858 / insulin like growth factor binding protein acid labile subunit  / reaction
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / reaction
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / reaction






 

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