ENSG00000182752


Homo sapiens

Features
Gene ID: ENSG00000182752
  
Biological name :PAPPA
  
Synonyms : PAPPA / pappalysin 1 / Q13219
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q33.1
Gene start: 116153804
Gene end: 116402322
  
Corresponding Affymetrix probe sets: 1558607_at (Human Genome U133 Plus 2.0 Array)   1558608_a_at (Human Genome U133 Plus 2.0 Array)   1559400_s_at (Human Genome U133 Plus 2.0 Array)   1559928_at (Human Genome U133 Plus 2.0 Array)   201981_at (Human Genome U133 Plus 2.0 Array)   201982_s_at (Human Genome U133 Plus 2.0 Array)   224940_s_at (Human Genome U133 Plus 2.0 Array)   224941_at (Human Genome U133 Plus 2.0 Array)   224942_at (Human Genome U133 Plus 2.0 Array)   228128_x_at (Human Genome U133 Plus 2.0 Array)   232748_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000330658
NCBI entrez gene - 5069     See in Manteia.
OMIM - 176385
RefSeq - XM_017014784
RefSeq - NM_002581
RefSeq - XM_006717129
RefSeq Peptide - NP_002572
swissprot - Q13219
Ensembl - ENSG00000182752
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pappaaENSDARG00000101090Danio rerio
 pappabENSDARG00000059858Danio rerio
 PAPPAENSGALG00000007079Gallus gallus
 PappaENSMUSG00000028370Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PAPPA2 / Q9BXP8 / pappalysin 2ENSG0000011618344


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000800  Notch domain
 IPR006558  LamG-like jellyroll fold
 IPR008754  Peptidase M43, pregnancy-associated plasma-A
 IPR011936  Myxococcus cysteine-rich repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR030433  Pappalysin-1
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0032354 response to follicle-stimulating hormone IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0051384 response to glucocorticoid IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity NAS
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115461 IGFBP5 / P24593 / insulin like growth factor binding protein 5  / reaction
 ENSG00000141753 IGFBP4 / P22692 / insulin like growth factor binding protein 4  / reaction
 ENSG00000099769 IGFALS / P35858 / insulin like growth factor binding protein acid labile subunit  / reaction
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / reaction
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / reaction






 

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