Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0000037	abnormal lateral semicircular canal	"anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1) Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129S/SvEv
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0000280	thin ventricular wall	"decreased depth of the cardiac wall of the heart ventricles" [J:45302]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0000380	small hair follicles	"reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0000556	abnormal hindlimb morphology	"malformation of the entire posterior extremities" [MGI:tc]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Atrn^mg/Atrn^mg Genetic Background: LDJ/Le
MP:0000734	muscle hypoplasia	"underdevelopment or atrophy of muscle" [J:15108]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Cd247^tm1Mhu/Cd247^tm1Mhu Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gad2^tm1Miya/Gad2^tm1Miya Genetic Background: NOD.129P2-Gad2^tm1Miya
MP:0000952	abnormal CNS glia	"anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gad2^tm1Miya/Gad2^tm1Miya Genetic Background: NOD.129P2-Gad2^tm1Miya
MP:0000953	abnormal oligodendrocyte morphology	"anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gad2^tm1Miya/Gad2^tm1Miya Genetic Background: NOD.129P2-Gad2^tm1Miya
MP:0000954	reduced oligodendrocyte progenitor number	"fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0001153	small seminiferous tubules	"reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001177	atelectasis	"collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0001201	translucent skin	"skin that is more transparent to light than normal " [J:15108]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0001216	abnormal epidermal layer morphology	"anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rbp4^tm1.1Mma/Rbp4^tm1.1Mma Genetic Background: involves: 129 * C57BL/6J
MP:0001218	thin epidermis	"reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0001238	thin epidermal spinous layer	"reduced thickness of the stratum spinosum; the polyhedral cell layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:15108]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0001257	increased body length	"increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Cd247^tm1Mhu/Cd247^tm1Mhu Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Cd247^tm1Mhu/Cd247^tm1Mhu Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Nkx2-1-cre)2Sand/0 Genetic Background: involves: C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Notch1^tm2Pst/Notch1^tm2.1Pst Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001386	abnormal maternal nurturing	"failure of mothers to tend offspring" [J:39801]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0001533	abnormal skeleton physiology	"anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Insr^tm1Khn/Insr^tm1Khn,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Notch1^tm2Pst/Notch1^tm2.1Pst Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv
MP:0001951	abnormal breathing	"irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1) Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129S/SvEv Allelic Composition: Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd247^tm1Mhu/Cd247^tm1Mhu Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N Allelic Composition: Eef1a1^{tm1(Kras)Arge}/Eef1a1⁺,Igf1r^tm2Arge/Igf1r⁺,Wap^tm1(cre)Arge/Wap⁺ Genetic Background:* involves: 129S1/Sv Allelic Composition: Eef1a1^{tm1(Kras)Arge}/Eef1a1⁺,Igf1r^tm2Arge/Igf1r^tm2Arge,Wap^tm1(cre)Arge/Wap⁺ Genetic Background:* involves: 129S1/Sv
MP:0002089	abnormal postnatal growth/weight/body size	"increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0002108	abnormal muscle morphology	"abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Notch1^tm2Pst/Notch1^tm2.1Pst Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0002188	small heart	"reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0002192	hydrops fetalis	"an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atrn^mg/Atrn^mg Genetic Background: LDJ/Le
MP:0002211	abnormal primary sex determination	"aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: T^9J/T^9J Genetic Background: C57BL/6J-T^9J Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Insr^tm1Dac/Insr⁺,Insrr^tm1Dac/Insrr^tm1Dac Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J
MP:0002335	decreased airway responsiveness	"less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0002428	abnormal semicircular canal	"anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002795	dilated cardiomyopathy	"decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0002858	abnormal posterior semicircular canal	"anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
MP:0002995	primary sex reversal	"gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: T^9J/T^9J Genetic Background: C57BL/6J-T^9J Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Insr^tm1Dac/Insr⁺,Insrr^tm1Dac/Insrr^tm1Dac Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Insr^tm1Dac/Insr^tm1Dac Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J
MP:0002996	ovotestis	"gonad with both ovarian and testicular tissue" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Insr^tm1Dac/Insr⁺,Insrr^tm1Dac/Insrr^tm1Dac Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J
MP:0003122	maternal imprinting	"specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129S/SvEv
MP:0003308	abnormal cochlear sensory epithelium		Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129S/SvEv
MP:0003893	increased hepatocyte proliferation	"anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0004003	abnormal vascular endothelial cell physiology	"anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hprt^{tm367a(Ple251-icre/ERT2)Ems}/Y Genetic Background: B6.Cg-Hprt^{tm367a(Ple251-icre/ERT2)Ems}
MP:0004259	small placenta	"reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2^tm1Rob Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2^tm1Rob,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2^tm1Rob,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2^tm1Rob,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
MP:0004260	enlarged placenta	"increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv
MP:0004289	abnormal bony labyrinth	"any structural abnormality in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0004393	abnormal cochlear inner hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0004396	decreased cochlear inner hair cell number	"decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0004399	abnormal cochlear outer hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0004402	decreased cochlear outer hair cell number	"decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0004408	decreased cochlear hair cell number	"decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0004521	abnormal cochlear hair cell stereociliary bundle morphology	"any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0004565	small myocardial fiber	"decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0004589	abnormal cochlear hair cell development	"atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0004883	abnormal blood vessel healing	"anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hprt^{tm367a(Ple251-icre/ERT2)Ems}/Y Genetic Background: B6.Cg-Hprt^{tm367a(Ple251-icre/ERT2)Ems}
MP:0004893	decreased adiponectin level	"reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
MP:0004985	decreased osteoclast cell number	"reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0004989	decreased osteoblast cell number	"reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005006	abnormal osteoblast function	"anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005164	abnormal response to injury	"anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Nkx2-1-cre)2Sand/0 Genetic Background: involves: C57BL/6 Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0005166	decreased susceptiblity to injury	"less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0005277	abnormal brainstem morphology	"anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Insr^tm1Khn/Insr^tm1Khn,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0005335	abnormal gonadal fat pad	"malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]	Show Allelic Composition: Cd247^tm1Mhu/Cd247^tm1Mhu Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
MP:0005597	decreased susceptibility to type I hypersensitivity reaction	"less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0005598	decreased ventricle muscle contractility	"reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0005608	cardiac interstitial fibrosis	"formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0006094	adipocyte hypertrophy	"increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * MF1 Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1 Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1 Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1 Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv
MP:0009115	abnormal fat cell morphology	"any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
MP:0009346	decreased cancellous bone thickness	"thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0009673	increased birth weight	"increase in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
MP:0009674	decreased birth weight	"reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1) Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2^tm1Rob Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2^tm1Rob,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2^tm1Rob,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2^tm1Rob,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
MP:0009728	abnormal calcaneum morphology	"any structural anomaly of the largest quadrangular bone at the back of the tarsus; it forms the heel or hock and articulates with the talus above it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
MP:0010299	increased mammary gland tumor incidence	"greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eef1a1^{tm1(Kras)Arge}/Eef1a1⁺,Igf1r^tm2Arge/Igf1r⁺,Wap^tm1(cre)Arge/Wap⁺ Genetic Background:* involves: 129S1/Sv Allelic Composition: Eef1a1^{tm1(Kras)Arge}/Eef1a1⁺,Igf1r^tm2Arge/Igf1r^tm2Arge,Wap^tm1(cre)Arge/Wap⁺ Genetic Background:* involves: 129S1/Sv
MP:0010725	thin interventricular septum	"decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0010862	decreased respiratory mucosa goblet cell number	"reduced number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0010865	prenatal growth retardation	"slow or limited development during the prenatal period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0010879	decreased trabecular bone volume	"decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0010897	abnormal bronchiole epithelium morphology	"any structural anomaly of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Nkx2-1-cre)2Sand/0 Genetic Background: involves: C57BL/6 Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0010901	abnormal pulmonary alveolar parenchyma morphology	"any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0011061	abnormal inner hair cell kinocilium morphology	"any structural anomaly of the nonmotile primary cilium that is found at the apical surface of inner hair cells" [GO:0060091]	Show Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz,Insr^tm1Khn/Insr^tm1Khn,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1 Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1 Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1 Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Irf8^tm1Hor/Irf8⁺ Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1) Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129S/SvEv Allelic Composition: Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N Allelic Composition: Igf1r^tm2.1Arge/Igf1r^tm2.1Arge Genetic Background: involves: 129 * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm2Arge/Igf2r^tm2Arge Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm2Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm1Arge/Igf2r⁺ Genetic Background: involves: 129/Sv * 129S/SvEv Allelic Composition: Igf1r^tm1Arge/Igf1r⁺,Igf2r^tm1Arge/Igf2r^tm1Arge Genetic Background: involves: 129/Sv * 129S/SvEv
MP:0020040	decreased bone ossification	"decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0020137	decreased bone mineralization	"decrease in the rate at which minerals are deposited into bone" []	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0020254	decreased collagen level	"decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0020344	abnormal susceptibility to injury induced morbidity/mortality	"differences from the expected moribund state caused by trauma, especially that by physical means" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0030279	thin neurocranium	"decreased thickness of the bones of the skull enclosing the brain" [MGI:anna]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J

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