ENSMUSG00000028072


Mus musculus

Features
Gene ID: ENSMUSG00000028072
  
Biological name :Ntrk1
  
Synonyms : High affinity nerve growth factor receptor / Ntrk1 / Q3UFB7
  
Possible biological names infered from orthology : neurotrophic receptor tyrosine kinase 1 / P04629
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 87778244
Gene end: 87795162
  
Corresponding Affymetrix probe sets: 10499247 (MoGene1.0st)   1443990_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029712
NCBI entrez gene - 18211     See in Manteia.
MGI - MGI:97383
RefSeq - NM_001033124
RefSeq - XM_006501124
RefSeq Peptide - NP_001028296
swissprot - Q3UFB7
Ensembl - ENSMUSG00000028072
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntrk1ENSDARG00000004586Danio rerio
 NTRK1ENSGALG00000019019Gallus gallus
 NTRK1ENSG00000198400Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG0000005914649
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG0000005525449
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG0000002667426
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553326
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728026
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG0000000353425
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553425
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564024
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989322
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547122
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG0000003530522
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG0000002397221
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146421
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG0000002729718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001611  Leucine-rich repeat
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020461  Tyrosine-protein kinase, neurotrophic receptor, type 1
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020777  Tyrosine-protein kinase, neurotrophic receptor
 IPR031635  Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0010623 programmed cell death involved in cell development IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0021553 olfactory nerve development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0031175 neuron projection development ISO
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:0038180 nerve growth factor signaling pathway IEA
 biological_processGO:0042490 mechanoreceptor differentiation IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043068 positive regulation of programmed cell death IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis ISO
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048485 sympathetic nervous system development IMP
 biological_processGO:0048666 neuron development ISO
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051599 response to hydrostatic pressure IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060009 Sertoli cell development IEA
 biological_processGO:0060384 innervation IMP
 biological_processGO:0060385 axonogenesis involved in innervation IMP
 biological_processGO:0061368 behavioral response to formalin induced pain IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071316 cellular response to nicotine IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity ISO
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IEA
 molecular_functionGO:0005030 neurotrophin receptor activity IEA
 molecular_functionGO:0005166 neurotrophin p75 receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0010465 nerve growth factor receptor activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0048406 nerve growth factor binding IEA


Pathways (from Reactome)
Pathway description
Frs2-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
TRKA activation by NGF
PI3K/AKT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000421 mottled coat "coat has spots, streaks, and/or blotches of a different color" [J:17194]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000578 ulcerated paws "inflammatory, often suppurating lesions on the paws; often become necrotic" [J:17194]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntf5tm1Par/Ntf5tm1Par,Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntrk1tm1Apat/Ntrk1tm1Apat
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Glg1Gt(RST092)Byg/Glg1+
Genetic Background: B6J.129P2-Apoetm1Unc Glg1Gt(RST092)Byg

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001490 abnormal vibrissae reflex "animals do not change position in response to stimulation of the whiskers" [J:17194]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0002003 meiotic pupils "charcterized by contraction of the pupils " [J:17194]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Lfr/Bdnftm1Lfr
Genetic Background: involves: 129S2/SvPas

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbxa2rtm1Cof/Tbxa2rtm1Cof
Genetic Background: involves: 129P2/OlaHsd

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129X1/SvJ-Col4a3tm1Dec

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129X1/SvJ-Col4a3tm1Dec

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129X1/SvJ-Col4a3tm1Dec

 MP:0002735 abnormal chemical nociception "abnormal capability to sense pain elicited by chemical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntrk1tm1Apat/Ntrk1tm1Apat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Tbxa2rtm1Cof/Tbxa2rtm1Cof
Genetic Background: involves: 129P2/OlaHsd

 MP:0003663 abnormal thermosensation "defect in the ability to sense or display a preference for a given temperature" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96549]
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Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat,Tg(Myog-Ntf3)5160Wds/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbxa2rtm1Cof/Tbxa2rtm1Cof
Genetic Background: involves: 129P2/OlaHsd

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129X1/SvJ-Col4a3tm1Dec

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
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Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0008467 absent proprioceptive neurons "absence of the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008485 increased muscle spindle number "greater number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129X1/SvJ-Col4a3tm1Dec

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129X1/SvJ-Col4a3tm1Dec

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbxa2rtm1Cof/Tbxa2rtm1Cof
Genetic Background: involves: 129P2/OlaHsd

 MP:0010055 abnormal sensory neuron physiology "any functional anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex
 ENSMUSG00000022420 Dnal4 / Q9DCM4 / Dynein light chain 4, axonemal / O96015* / dynein axonemal light chain 4*  / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000028072 Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / complex
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / complex
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / complex
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction / complex
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / reaction / complex






 

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