ENSMUSG00000022841


Mus musculus

Features
Gene ID: ENSMUSG00000022841
  
Biological name :Ap2m1
  
Synonyms : AP-2 complex subunit mu / Ap2m1 / P84091
  
Possible biological names infered from orthology : adaptor related protein complex 2 mu 1 subunit / Q96CW1
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 20535478
Gene end: 20544909
  
Corresponding Affymetrix probe sets: 10434384 (MoGene1.0st)   1450894_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007216
Ensembl peptide - ENSMUSP00000087477
NCBI entrez gene - 11773     See in Manteia.
MGI - MGI:1298405
RefSeq - NM_009679
RefSeq - NM_001302970
RefSeq Peptide - NP_001289899
RefSeq Peptide - NP_033809
swissprot - P84091
swissprot - Q3TWV4
swissprot - Q5FWI9
Ensembl - ENSMUSG00000022841
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap2m1aENSDARG00000002790Danio rerio
 ap2m1bENSDARG00000033899Danio rerio
 AP2M1ENSGALG00000008432Gallus gallus
 AP2M1ENSG00000161203Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ap1m2 / adaptor related protein complex 1 mu 2 subunit / Q9Y6Q5*ENSMUSG0000000330940
Ap1m1 / P35585 / AP-1 complex subunit mu-1 / Q9BXS5* / adaptor related protein complex 1 mu 1 subunit*ENSMUSG0000000303339
Ap4m1 / Q9JKC7 / AP-4 complex subunit mu-1 / O00189* / adaptor related protein complex 4 mu 1 subunit*ENSMUSG0000001951829
Ap3m1 / Q9JKC8 / AP-3 complex subunit mu-1 / Q9Y2T2* / adaptor related protein complex 3 mu 1 subunit*ENSMUSG0000002182425
Ap3m2 / Q8R2R9 / AP-3 complex subunit mu-2 / P53677* / adaptor related protein complex 3 mu 2 subunit*ENSMUSG0000003153925


Protein motifs (from Interpro)
Interpro ID Name
 IPR001392  Clathrin adaptor, mu subunit
 IPR011012  Longin-like domain superfamily
 IPR018240  Clathrin adaptor, mu subunit, conserved site
 IPR022775  AP complex, mu/sigma subunit
 IPR028565  Mu homology domain
 IPR036168  AP-2 complex subunit mu, C-terminal superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016050 vesicle organization ISO
 biological_processGO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane IEA
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0031623 receptor internalization ISO
 biological_processGO:0097494 regulation of vesicle size ISO
 biological_processGO:1900244 positive regulation of synaptic vesicle endocytosis IEA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane ISO
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030141 secretory granule TAS
 cellular_componentGO:0043195 terminal bouton IEA
 molecular_functionGO:0005048 signal sequence binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IDA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
Trafficking of GluR2-containing AMPA receptors
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / complex
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex / reaction
 ENSMUSG00000049791 Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*  / reaction / complex
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / complex
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / complex
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / complex / reaction
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / reaction / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / complex
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / complex / reaction
 ENSMUSG00000047547 Cltb / Q6IRU5 / Clathrin light chain B / P09497*  / complex
 ENSMUSG00000021994 Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*  / complex / reaction
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000068206 Pick1 / protein interacting with C kinase 1 / Q9NRD5* / protein interacting with PRKCA 1*  / reaction
 ENSMUSG00000022420 Dnal4 / Q9DCM4 / Dynein light chain 4, axonemal / O96015* / dynein axonemal light chain 4*  / reaction
 ENSMUSG00000024924 Vldlr / P98156 / very low density lipoprotein receptor / P98155*  / complex / reaction
 ENSMUSG00000032193 Ldlr / P35951 / Low-density lipoprotein receptor / P01130*  / complex / reaction
 ENSMUSG00000028072 Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*  / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex
 ENSMUSG00000034813 Grip1 / Q925T6 / Glutamate receptor-interacting protein 1 / Q9Y3R0*  / reaction
 ENSMUSG00000034311 Kif4 / P33174 / Chromosome-associated kinesin KIF4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / kinesin family member 4B* / kinesin family member 4A*  / complex
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction
 ENSMUSG00000044254 Pcsk9 / Q80W65 / Proprotein convertase subtilisin/kexin type 9 / Q8NBP7*  / complex / reaction






 

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