ENSMUSG00000001986


Mus musculus

Features
Gene ID: ENSMUSG00000001986
  
Biological name :Gria3
  
Synonyms : Gria3 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / Q9Z2W9
  
Possible biological names infered from orthology : glutamate ionotropic receptor AMPA type subunit 3 / P42263
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A4
Gene start: 41400854
Gene end: 41678601
  
Corresponding Affymetrix probe sets: 10599348 (MoGene1.0st)   1420563_at (Mouse Genome 430 2.0 Array)   1434728_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075687
Ensembl peptide - ENSMUSP00000116381
Ensembl peptide - ENSMUSP00000117766
Ensembl peptide - ENSMUSP00000131523
Ensembl peptide - ENSMUSP00000110755
NCBI entrez gene - 53623     See in Manteia.
MGI - MGI:95810
RefSeq - XM_017318547
RefSeq - NM_001281929
RefSeq - NM_001290451
RefSeq - NM_001358361
RefSeq - NM_016886
RefSeq - XM_006541520
RefSeq - XM_011251015
RefSeq - XM_017318545
RefSeq - XM_017318546
RefSeq Peptide - NP_001345290
RefSeq Peptide - NP_058582
RefSeq Peptide - NP_001268858
RefSeq Peptide - NP_001277380
swissprot - Q9Z2W9
swissprot - B0QZW2
swissprot - F2Z488
swissprot - B0QZW1
Ensembl - ENSMUSG00000001986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gria3aENSDARG00000032737Danio rerio
 gria3bENSDARG00000037498Danio rerio
 GRIA3ENSGALG00000034109Gallus gallus
 GRIA3ENSG00000125675Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gria2 / glutamate receptor 2 isoform 3 / P42262* / glutamate ionotropic receptor AMPA type subunit 2*ENSMUSG0000003398171
Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*ENSMUSG0000002589271
Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*ENSMUSG0000002052467
Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*ENSMUSG0000005607338
Grik1 / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA. / P39086* / glutamate ionotropic receptor kainate type subunit 1*ENSMUSG0000002293538
Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*ENSMUSG0000000198536
Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*ENSMUSG0000003201735
Grik5 / Q61626 / Glutamate receptor ionotropic, kainate 5 / Q16478* / glutamate ionotropic receptor kainate type subunit 5*ENSMUSG0000000337834
Grid1 / Q61627 / Glutamate receptor ionotropic, delta-1 / Q9ULK0* / glutamate ionotropic receptor delta type subunit 1*ENSMUSG0000004107826
Grid2 / Q61625 / Glutamate receptor ionotropic, delta-2 / O43424* / glutamate ionotropic receptor delta type subunit 2*ENSMUSG0000007142425
Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*ENSMUSG0000002073421
Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*ENSMUSG0000005900320
Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*ENSMUSG0000003020920
Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*ENSMUSG0000000277120
Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*ENSMUSG0000002695920
Grin3b / Q91ZU9 / Glutamate receptor ionotropic, NMDA 3B / O60391* / glutamate ionotropic receptor NMDA type subunit 3B*ENSMUSG0000003574519
Grin3a / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSMUSG0000003957918


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0004971 AMPA glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of AMPA receptors
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Axin1Fu-ki/Axin1Fu-ki
Genetic Background: involves: Bagg albino * CF * fanciers mice

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ddotm1Rdl/Ddotm1Rdl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Scn11atm1Dgen/Scn11a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Scn11atm1Dgen/Scn11a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Scn11atm1Dgen/Scn11a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
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Allelic Composition: Gria3tm1Dgen/Gria3tm1Dgen,Gria4spkw1/Gria4spkw1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddotm1Rdl/Ddotm1Rdl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Ddotm1Rdl/Ddotm1Rdl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / reaction
 ENSMUSG00000068206 Pick1 / protein interacting with C kinase 1 / Q9NRD5* / protein interacting with PRKCA 1*  / reaction
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction / complex
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction / complex
 ENSMUSG00000034813 Grip1 / Q925T6 / Glutamate receptor-interacting protein 1 / Q9Y3R0*  / reaction
 ENSMUSG00000030600 Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*  / reaction / complex
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / reaction
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / complex / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / reaction
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / reaction
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / reaction






 

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