ENSMUSG00000026959


Mus musculus

Features
Gene ID: ENSMUSG00000026959
  
Biological name :Grin1
  
Synonyms : Glutamate receptor ionotropic, NMDA 1 / Grin1 / P35438
  
Possible biological names infered from orthology : glutamate ionotropic receptor NMDA type subunit 1 / Q05586
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 25291181
Gene end: 25319187
  
Corresponding Affymetrix probe sets: 10480676 (MoGene1.0st)   1437968_at (Mouse Genome 430 2.0 Array)   1450202_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109946
Ensembl peptide - ENSMUSP00000109957
Ensembl peptide - ENSMUSP00000109956
Ensembl peptide - ENSMUSP00000109953
Ensembl peptide - ENSMUSP00000109951
Ensembl peptide - ENSMUSP00000109949
Ensembl peptide - ENSMUSP00000109947
Ensembl peptide - ENSMUSP00000028335
NCBI entrez gene - 14810     See in Manteia.
MGI - MGI:95819
RefSeq - XM_006497726
RefSeq - NM_001177656
RefSeq - NM_001177657
RefSeq - NM_008169
RefSeq - XM_006497722
RefSeq - XM_006497723
RefSeq - XM_006497724
RefSeq - XM_006497725
RefSeq Peptide - NP_001171127
RefSeq Peptide - NP_032195
RefSeq Peptide - NP_001171128
swissprot - A2AI16
swissprot - A2AI14
swissprot - A2AI20
swissprot - A2AI21
swissprot - P35438
swissprot - A2AI19
swissprot - A2AI17
Ensembl - ENSMUSG00000026959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grin1aENSDARG00000027828Danio rerio
 grin1bENSDARG00000025728Danio rerio
 GRIN1ENSGALG00000008898Gallus gallus
 GRIN1ENSG00000176884Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*ENSMUSG0000005900325
Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*ENSMUSG0000003020925
Grin3a / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSMUSG0000003957923
Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*ENSMUSG0000002073423
Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*ENSMUSG0000000277123
Grin3b / Q91ZU9 / Glutamate receptor ionotropic, NMDA 3B / O60391* / glutamate ionotropic receptor NMDA type subunit 3B*ENSMUSG0000003574522
Grik5 / Q61626 / Glutamate receptor ionotropic, kainate 5 / Q16478* / glutamate ionotropic receptor kainate type subunit 5*ENSMUSG0000000337821
Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*ENSMUSG0000003201720
Grik1 / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA. / P39086* / glutamate ionotropic receptor kainate type subunit 1*ENSMUSG0000002293520
Gria2 / glutamate receptor 2 isoform 3 / P42262* / glutamate ionotropic receptor AMPA type subunit 2*ENSMUSG0000003398120
Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*ENSMUSG0000000198519
Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*ENSMUSG0000002589219
Grid2 / Q61625 / Glutamate receptor ionotropic, delta-2 / O43424* / glutamate ionotropic receptor delta type subunit 2*ENSMUSG0000007142419
Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*ENSMUSG0000002052419
Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*ENSMUSG0000005607319
Grid1 / Q61627 / Glutamate receptor ionotropic, delta-1 / Q9ULK0* / glutamate ionotropic receptor delta type subunit 1*ENSMUSG0000004107819
Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*ENSMUSG0000000198619


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR018882  Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001661 conditioned taste aversion IMP
 biological_processGO:0001964 startle response IMP
 biological_processGO:0001967 suckling behavior IMP
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport ISO
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0008355 olfactory learning IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0010646 regulation of cell communication IMP
 biological_processGO:0018964 propylene metabolic process IDA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0021586 pons maturation IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IDA
 biological_processGO:0035249 synaptic transmission, glutamatergic IMP
 biological_processGO:0042391 regulation of membrane potential ISO
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0043278 response to morphine IMP
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043576 regulation of respiratory gaseous exchange IMP
 biological_processGO:0045471 response to ethanol ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IMP
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0048814 regulation of dendrite morphogenesis IMP
 biological_processGO:0050770 regulation of axonogenesis IMP
 biological_processGO:0050905 neuromuscular process IMP
 biological_processGO:0051290 protein heterotetramerization ISS
 biological_processGO:0051963 regulation of synapse assembly IMP
 biological_processGO:0055074 calcium ion homeostasis IDA
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0060134 prepulse inhibition IMP
 biological_processGO:0060179 male mating behavior IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0097553 calcium ion transmembrane import into cytosol ISO
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:1903539 protein localization to postsynaptic membrane IMP
 biological_processGO:1905429 response to glycine ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0009986 cell surface IMP
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IMP
 cellular_componentGO:0030426 growth cone NAS
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0045211 postsynaptic membrane IDA
 cellular_componentGO:0098839 postsynaptic density membrane IDA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0004972 NMDA glutamate receptor activity ISO
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IGI
 molecular_functionGO:0005262 calcium channel activity ISO
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IDA
 molecular_functionGO:0016594 glycine binding ISS
 molecular_functionGO:0016595 glutamate binding ISO
 molecular_functionGO:0022849 glutamate-gated calcium ion channel activity ISO
 molecular_functionGO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IMP


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000860 abnormal primary somatosensory cortex morphology "any malformation or absence of the area of the postcentral gyrus and central sulcus that is involved in somatic sensation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000862 absent barrels in primary somatosensory cortex "missing pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:64064]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm2Blt/Grin1tm2Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm1.1Ese/Grin1tm1.1Ese
Genetic Background: involves: C57BL/6

Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

Allelic Composition: Grin1Rgsc174/Grin1+
Genetic Background: C57BL/6J-Grin1Rgsc174

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Grin1tm1Jjwd/Grin1tm1Jjwd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Grin1tm1.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Grin1tm1Blt/Grin1tm1Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm1.1Slab/Grin1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Grin1Rgsc174/Grin1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Grin1tm1.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

Allelic Composition: Grin1Rgsc174/Grin1+
Genetic Background: C57BL/6J-Grin1Rgsc174

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Grin1tm2.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Grin1Rgsc174/Grin1+
Genetic Background: C57BL/6J-Grin1Rgsc174

 MP:0001423 abnormal liquid preference "the desire to drink more or less fluids than average, or to drink unusual fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Grin1tm2Stl/Grin1tm2Stl
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0001435 no suckling reflex "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Grin1tm1Blt/Grin1tm1Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Irak1tm1Jth/Y
Genetic Background: B6.Cg-Irak1tm1Jth

Allelic Composition: Grin1tm1Cur/Grin1tm2.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1.1Phs/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1Cur/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Grin1tm1.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0001448 abnormal huddling behavior "deviation from the usual tendency of mice to pile together when sleeping" [What s wrong with my mouse?:ISBN 0-471-31639-3, J:42758]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ

 MP:0001460 abnormal olfactory -discrimination memory "defects in the ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Actb-tTA)1Jzt/0,Tg(Camk2a-cre)T29-1Stl/0,Tg(tetO-Grin1/GFP)1Jzt/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grin1tm1Stl/Grin1+,Nf1tm1Tyj/Nf1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Actb-tTA)1Jzt/0,Tg(Camk2a-cre)T29-1Stl/0,Tg(tetO-Grin1/GFP)1Jzt/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Grin1tm1Blt/Grin1tm1Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: C57BL/6

Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Grin1tm1.1Ese/Grin1tm1.1Ese
Genetic Background: involves: C57BL/6

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm1Blt/Grin1tm1Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Grin1tm2.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm1Stl/Grin1tm1Stl
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

Allelic Composition: Grin1tm1.1Phs/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1Cur/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grin1tm2.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Per1tm1Brd/Per1tm1Brd,Per2tm1Brd/Per2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001901 absence of NMDA -mediated synaptic currents "absence of a measured amplitude or response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm1Stl/Grin1tm1Stl
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Actb-tTA)1Jzt/0,Tg(Camk2a-cre)T29-1Stl/0,Tg(tetO-Grin1/GFP)1Jzt/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Gnrh1-cre)1Rsp/0
Genetic Background: involves: C57BL/6

Allelic Composition: Grin1tm1Cur/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnmb1tm1Ltor/Kcnmb1tm1Ltor
Genetic Background: Not Specified

Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N * SJL

 MP:0001909 reduced NMDA receptor mediated synaptic activity in barrel cortex "lower than normal levels of excitatory synaptic current in the barrel cortex" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:64064]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Grin1tm1Stl/Grin1tm2Stl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irak1tm1Jth/Y
Genetic Background: B6.Cg-Irak1tm1Jth

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Grin1tm1.1Phs/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1Cur/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Grin1tm1.1Slab/Grin1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Grin1tm1Cur/Grin1tm2.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1.1Phs/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1Cur/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
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Allelic Composition: Grin1tm1Stl/Grin1tm1Stl
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6)

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Actb-tTA)1Jzt/0,Tg(Camk2a-cre)62Jzt/0,Tg(tetO-Grin1/GFP)1Jzt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm2.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Grin1tm2Stl/Grin1tm2Stl
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grin1tm1.1Slab/Grin1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Grin1tm1.1Phs/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm1.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hist1h1ttm1.1(mm)Ddra/Hist1h1t+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1.1Ese/Grin1tm1.1Ese
Genetic Background: involves: C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0002802 abnormal discrimination learning "defects in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Per1tm1Brd/Per1tm1Brd,Per2tm1Brd/Per2tm1.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Actb-tTA)1Jzt/0,Tg(Camk2a-cre)62Jzt/0,Tg(tetO-Grin1/GFP)1Jzt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Grin1tm1Jjwd/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Grin1tm1.1Ese/Grin1tm1.1Ese
Genetic Background: involves: C57BL/6

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Grin1tm1Blt/Grin1tm1Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002888 abnormal NMDA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: C57BL/6

Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Grin1tm1.1Phs/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL

Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N * SJL

Allelic Composition: Grin1tm1Jjwd/Grin1tm1Jjwd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Grin1tm1Jjwd/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa
Genetic Background: Not Specified

 MP:0002969 impaired social transmission of food preference "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [J:62218]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0002980 abnormal postural reflex "failure to respond with the normal extension of legs to maintain balance when the cage is tilted" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88306]
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Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: C57BL/6

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Grin1tm1Jjwd/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Grin1tm1Jjwd/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Grin1tm1Blt/Grin1tm1Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grin1tm2Blt/Grin1tm2Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003863 decreased aggression towards mice "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Grin1Rgsc174/Grin1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa
Genetic Background: Not Specified

Allelic Composition: Grin1tm1.1Ese/Grin1tm1.1Ese
Genetic Background: involves: C57BL/6

Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL

Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N * SJL

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Grin1Rgsc174/Grin1+
Genetic Background: C57BL/6J-Grin1Rgsc174

Allelic Composition: Grin1Rgsc174/Grin1Rgsc174
Genetic Background: C57BL/6J-Grin1Rgsc174

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Grin1tm1Stl/Grin1tm1Stl
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grin1tm2.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005572 abnormal breathing frequency "deviation from the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Grin1tm1Cur/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0008462 abnormal medium spiny neuron morphology "any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [PMID:15504319]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1Rgsc174/Grin1+
Genetic Background: C57BL/6J-Grin1Rgsc174

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm1.1Ese/Grin1tm1.1Ese
Genetic Background: involves: C57BL/6

Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0009327 abnormal maternal grooming "females do not elicit the cleaning or tactile stimulus level necessary to initiate nursing by offspring" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

Allelic Composition: Grin1tm1.1Phs/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1Cur/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa
Genetic Background: Not Specified

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1Rgsc174/Grin1+
Genetic Background: C57BL/6J-Grin1Rgsc174

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1.1Ese/Grin1tm1.1Ese
Genetic Background: involves: C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grin1tm2.1Phs/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Grin1tm1Jjwd/Grin1tm1Jjwd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Grin1Rgsc174/Grin1Rgsc174
Genetic Background: C57BL/6J-Grin1Rgsc174

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Grin1tm1Stl/Grin1tm1Stl
Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Grin1tm1Slab/Grin1tm1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Grin1tm1.1Slab/Grin1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Grin1tm2Phs/Grin1tm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Grin1tm1Cur/Grin1tm2.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

Allelic Composition: Grin1tm1.1Phs/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grin1tm1Cur/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gja8No2/Gja8+
Genetic Background: involves: 101 * C3H

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Grin1Rgsc174/Grin1Rgsc174
Genetic Background: C57BL/6J-Grin1Rgsc174

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL

Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N * SJL

 MP:0020157 abnormal behavioral response to alcohol "any anomaly in the behavioral response induced by alcohol, such as induced hyperactivity or stereotypic behavior" [GOC:NV]
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Allelic Composition: Grin1tm1Jjwd/Grin1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / complex / reaction
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / complex
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / complex
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / complex / reaction
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / complex
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex
 ENSMUSG00000032356 P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*  / complex / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction / complex
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction / complex
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000014932 Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*  / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / complex
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / reaction / complex
 ENSMUSG00000040490 Lrfn2 / Q80TG9 / Leucine-rich repeat and fibronectin type-III domain-containing protein 2 / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*  / complex / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex
 ENSMUSG00000030600 Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction






 

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