ENSGALG00000008898


Gallus gallus

Features
Gene ID: ENSGALG00000008898
  
Biological name :GRIN1
  
Synonyms : glutamate ionotropic receptor NMDA type subunit 1 / GRIN1
  
Possible biological names infered from orthology : Glutamate receptor ionotropic, NMDA 1 / P35438 / Q05586
  
Species: Gallus gallus
  
Chr. number: 17
Strand: -1
Band:
Gene start: 1495117
Gene end: 1523559
  
Corresponding Affymetrix probe sets: Gga.12184.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000039568
NCBI entrez gene - 404296     See in Manteia.
RefSeq - XM_015279362
RefSeq - NM_206979
RefSeq - XM_015279359
RefSeq - XM_015279360
RefSeq - XM_015279348
RefSeq - XM_015279349
RefSeq - XM_015279351
RefSeq - XM_015279352
RefSeq - XM_015279353
RefSeq - XM_015279354
RefSeq - XM_015279355
RefSeq - XM_015279356
RefSeq - XM_015279357
RefSeq - XM_015279358
RefSeq Peptide - NP_996862
swissprot - Q6R6I2
Ensembl - ENSGALG00000008898
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grin1aENSDARG00000027828Danio rerio
 grin1bENSDARG00000025728Danio rerio
 GRIN1ENSG00000176884Homo sapiens
 Grin1ENSMUSG00000026959Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRIN2A / glutamate ionotropic receptor NMDA type subunit 2A / P35436* / Q12879* / Glutamate receptor ionotropic, NMDA 2A *ENSGALG0000000727823
GRIN2C / glutamate ionotropic receptor NMDA type subunit 2C / Q01098* / Q14957* / Glutamate receptor ionotropic, NMDA 2C *ENSGALG0000002741523
GRIN3A / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSGALG0000001555120
GRIN3B / glutamate ionotropic receptor NMDA type subunit 3B / O60391* / Q91ZU9* / Glutamate receptor ionotropic, NMDA 3B *ENSGALG0000002624120
GRIA2 / glutamate receptor 2 isoform 1 precursor / P42262* / glutamate receptor 2 isoform 3 * / glutamate ionotropic receptor AMPA type subunit 2*ENSGALG0000000940519
GRIK1 / glutamate ionotropic receptor kainate type subunit 1 / P39086* / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA.*ENSGALG0000001583519
GRIK2 / glutamate ionotropic receptor kainate type subunit 2 / P39087* / Q13002* / Glutamate receptor ionotropic, kainate 2 *ENSGALG0000001543419
GRIK3 / glutamate ionotropic receptor kainate type subunit 3 / B1AS29* / Q13003* / Glutamate receptor ionotropic, kainate 3 *ENSGALG0000000209819
GRIA1 / glutamate ionotropic receptor AMPA type subunit 1 / P23818* / P42261* / Glutamate receptor 1 *ENSGALG0000000408318
GRIA4 / glutamate receptor 4 isoform 1 precursor / P48058* / Q9Z2W8* / glutamate receptor, ionotropic, AMPA4 (alpha 4)* / glutamate ionotropic receptor AMPA type subunit 4*ENSGALG0000003899518
GRID2 / glutamate ionotropic receptor delta type subunit 2 / O43424* / Q61625* / Glutamate receptor ionotropic, delta-2 *ENSGALG0000001039718
GRIA3 / glutamate receptor 3 isoform 2 precursor / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gr...ENSGALG0000003410918
GRIK4 / glutamate ionotropic receptor kainate type subunit 4 / Q16099* / Q8BMF5* / Glutamate receptor ionotropic, kainate 4 *ENSGALG0000000663818
GRID1 / glutamate ionotropic receptor delta type subunit 1 / Q61627* / Q9ULK0* / Glutamate receptor ionotropic, delta-1 *ENSGALG0000003736617
GRIN2B* / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)*ENSGALG0000004134814
KBP / P19439 / Probable glutamate receptor ENSGALG0000000117212
GRIN2B* / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)*ENSGALG0000001180911


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR018882  Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001661 conditioned taste aversion IEA
 biological_processGO:0001964 startle response IEA
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007585 respiratory gaseous exchange IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0008355 olfactory learning IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010646 regulation of cell communication IEA
 biological_processGO:0018964 propylene metabolic process IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0021586 pons maturation IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043576 regulation of respiratory gaseous exchange IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IEA
 biological_processGO:0050770 regulation of axonogenesis IEA
 biological_processGO:0050905 neuromuscular process IEA
 biological_processGO:0051963 regulation of synapse assembly IEA
 biological_processGO:0055074 calcium ion homeostasis IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060134 prepulse inhibition IEA
 biological_processGO:0060179 male mating behavior IEA
 biological_processGO:0097553 calcium ion transmembrane import into cytosol IEA
 biological_processGO:1903539 protein localization to postsynaptic membrane IEA
 biological_processGO:1905429 response to glycine IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098839 postsynaptic density membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0004972 NMDA glutamate receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0016594 glycine binding IEA
 molecular_functionGO:0016595 glutamate binding IEA
 molecular_functionGO:0022849 glutamate-gated calcium ion channel activity IEA
 molecular_functionGO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000314 NEFL / neurofilament light / P07196* / P08551* / Neurofilament light polypeptide *  / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / complex
 ENSGALG00000004083 GRIA1 / glutamate ionotropic receptor AMPA type subunit 1 / P23818* / P42261* / Glutamate receptor 1 *  / reaction
 ENSGALG00000005621 CAMK2A / calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798* / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / complex / reaction
 ENSGALG00000007278 GRIN2A / glutamate ionotropic receptor NMDA type subunit 2A / P35436* / Q12879* / Glutamate receptor ionotropic, NMDA 2A *  / complex
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex
 ENSGALG00000014463 ACTN2 / P20111 / Alpha-actinin-2 / P35609* / Q9JI91* / actinin alpha 2*  / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSGALG00000014860 YES1 / P09324 / Tyrosine-protein kinase Yes / Q04736* / P07947* / YES proto-oncogene 1, Src family tyrosine kinase*  / complex
 ENSGALG00000015842 TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*  / complex / reaction
 ENSGALG00000027415 GRIN2C / glutamate ionotropic receptor NMDA type subunit 2C / Q01098* / Q14957* / Glutamate receptor ionotropic, NMDA 2C *  / complex
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000015598 RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2 / O14827* / ras-specific guanine nucleotide-releasing factor 2 *  / complex / reaction
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / complex
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / complex
 ENSGALG00000038995 GRIA4 / glutamate receptor 4 isoform 1 precursor / P48058* / Q9Z2W8* / glutamate receptor, ionotropic, AMPA4 (alpha 4)* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSGALG00000042321 LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex
 ENSGALG00000040724 AKAP9 / A-kinase anchoring protein 9 / Q99996*  / complex






 

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