ENSGALG00000004083


Gallus gallus

Features
Gene ID: ENSGALG00000004083
  
Biological name :GRIA1
  
Synonyms : glutamate ionotropic receptor AMPA type subunit 1 / GRIA1
  
Possible biological names infered from orthology : Glutamate receptor 1 / P23818 / P42261
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 12326556
Gene end: 12434427
  
Corresponding Affymetrix probe sets: Gga.942.1.S1_at (Chicken Array)   Gga.942.1.S1_s_at (Chicken Array)   Gga.943.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052753
Ensembl peptide - ENSGALP00000006483
NCBI entrez gene - 414893     See in Manteia.
RefSeq - XM_015293757
RefSeq - NM_001001774
RefSeq - XM_015293755
RefSeq - XM_015293756
RefSeq Peptide - NP_001001774
swissprot - A0A1D5PIW7
swissprot - Q90855
Ensembl - ENSGALG00000004083
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gria1aENSDARG00000021352Danio rerio
 gria1bENSDARG00000032714Danio rerio
 GRIA1ENSG00000155511Homo sapiens
 Gria1ENSMUSG00000020524Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRIA2 / glutamate receptor 2 isoform 1 precursor / P42262* / glutamate receptor 2 isoform 3 * / glutamate ionotropic receptor AMPA type subunit 2*ENSGALG0000000940568
GRIA3 / glutamate receptor 3 isoform 2 precursor / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gr...ENSGALG0000003410966
GRIA4 / glutamate receptor 4 isoform 1 precursor / P48058* / Q9Z2W8* / glutamate receptor, ionotropic, AMPA4 (alpha 4)* / glutamate ionotropic receptor AMPA type subunit 4*ENSGALG0000003899566
GRIK2 / glutamate ionotropic receptor kainate type subunit 2 / P39087* / Q13002* / Glutamate receptor ionotropic, kainate 2 *ENSGALG0000001543438
GRIK1 / glutamate ionotropic receptor kainate type subunit 1 / P39086* / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA.*ENSGALG0000001583537
GRIK3 / glutamate ionotropic receptor kainate type subunit 3 / B1AS29* / Q13003* / Glutamate receptor ionotropic, kainate 3 *ENSGALG0000000209837
GRIK4 / glutamate ionotropic receptor kainate type subunit 4 / Q16099* / Q8BMF5* / Glutamate receptor ionotropic, kainate 4 *ENSGALG0000000663831
GRID1 / glutamate ionotropic receptor delta type subunit 1 / Q61627* / Q9ULK0* / Glutamate receptor ionotropic, delta-1 *ENSGALG0000003736626
GRID2 / glutamate ionotropic receptor delta type subunit 2 / O43424* / Q61625* / Glutamate receptor ionotropic, delta-2 *ENSGALG0000001039723
GRIN2A / glutamate ionotropic receptor NMDA type subunit 2A / P35436* / Q12879* / Glutamate receptor ionotropic, NMDA 2A *ENSGALG0000000727821
GRIN2C / glutamate ionotropic receptor NMDA type subunit 2C / Q01098* / Q14957* / Glutamate receptor ionotropic, NMDA 2C *ENSGALG0000002741521
GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *ENSGALG0000000889820
KBP / P19439 / Probable glutamate receptor ENSGALG0000000117219
GRIN3B / glutamate ionotropic receptor NMDA type subunit 3B / O60391* / Q91ZU9* / Glutamate receptor ionotropic, NMDA 3B *ENSGALG0000002624118
GRIN3A / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSGALG0000001555117
GRIN2B* / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)*ENSGALG0000004134812
GRIN2B* / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)*ENSGALG000000118099


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001661 conditioned taste aversion IDA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007613 memory IDA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060292 long term synaptic depression IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IBA
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032591 dendritic spine membrane IEA
 cellular_componentGO:0036477 somatodendritic compartment IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044308 axonal spine IEA
 cellular_componentGO:0044309 neuron spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0097060 synaptic membrane IDA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0098839 postsynaptic density membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0004971 AMPA glutamate receptor activity IBA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IEA
 molecular_functionGO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Activation of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Cargo concentration in the ER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004083 GRIA1 / glutamate ionotropic receptor AMPA type subunit 1 / P23818* / P42261* / Glutamate receptor 1 *  / complex / reaction
 ENSGALG00000007278 GRIN2A / glutamate ionotropic receptor NMDA type subunit 2A / P35436* / Q12879* / Glutamate receptor ionotropic, NMDA 2A *  / reaction
 ENSGALG00000038995 GRIA4 / glutamate receptor 4 isoform 1 precursor / P48058* / Q9Z2W8* / glutamate receptor, ionotropic, AMPA4 (alpha 4)* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction / complex
 ENSGALG00000040724 AKAP9 / A-kinase anchoring protein 9 / Q99996*  / reaction
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / reaction
 ENSGALG00000027415 GRIN2C / glutamate ionotropic receptor NMDA type subunit 2C / Q01098* / Q14957* / Glutamate receptor ionotropic, NMDA 2C *  / reaction
 ENSGALG00000041823 PICK1 / protein interacting with PRKCA 1 / Q9NRD5* / protein interacting with C kinase 1*  / reaction
 ENSGALG00000005621 CAMK2A / calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798* / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSGALG00000014463 ACTN2 / P20111 / Alpha-actinin-2 / P35609* / Q9JI91* / actinin alpha 2*  / reaction
 ENSGALG00000009308 CNIH3 / cornichon family AMPA receptor auxiliary protein 3 / 3 * / Q6ZWS4* / Q8TBE1*  / complex / reaction
 ENSGALG00000000314 NEFL / neurofilament light / P07196* / P08551* / Neurofilament light polypeptide *  / reaction
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / reaction
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / reaction






 

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