ENSGALG00000005621


Gallus gallus

Features
Gene ID: ENSGALG00000005621
  
Biological name :CAMK2A
  
Synonyms : calcium/calmodulin-dependent protein kinase type II subunit alpha / CAMK2A
  
Possible biological names infered from orthology : calcium/calmodulin dependent protein kinase II alpha / P11798 / Q9UQM7
  
Species: Gallus gallus
  
Chr. number: 13
Strand: 1
Band:
Gene start: 13192090
Gene end: 13212308
  
Corresponding Affymetrix probe sets: Gga.9623.1.S1_a_at (Chicken Array)   GgaAffx.3527.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000049737
Ensembl peptide - ENSGALP00000057164
Ensembl peptide - ENSGALP00000009006
Ensembl peptide - ENSGALP00000039686
NCBI entrez gene - 374175     See in Manteia.
RefSeq - XM_015293721
RefSeq - NM_204295
RefSeq - XM_015293719
RefSeq - XM_015293720
RefSeq Peptide - NP_989626
swissprot - A0A1D5PAH4
swissprot - A0A1D5PW35
swissprot - F1NGS8
swissprot - F1P011
Ensembl - ENSGALG00000005621
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camk2aENSDARG00000053617Danio rerio
 CAMK2AENSG00000070808Homo sapiens
 Camk2aENSMUSG00000024617Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAMK2D / calcium/calmodulin-dependent protein kinase type II delta chain / Q13557* / Q6PHZ2* / calcium/calmodulin dependent protein kinase II delta* / Mus musculus calcium/calmodulin-depen...ENSGALG0000004163583
CAMK2B* / P28652* / Q13554* / calcium/calmodulin dependent protein kinase II beta* / Calcium/calmodulin-dependent protein kinase type II subunit beta *ENSGALG0000003306181
CAMK2G / calcium/calmodulin dependent protein kinase II gamma / Q13555* / Q923T9* / Calcium/calmodulin-dependent protein kinase type II subunit gamma *ENSGALG0000000508877
CAMK1 / calcium/calmodulin dependent protein kinase I / Q14012* / Q91YS8*ENSGALG0000002991228
ENSGALG0000001520328
CAMK4 / calcium/calmodulin-dependent protein kinase type IV / Q16566* / calcium/calmodulin dependent protein kinase IV*ENSGALG0000000024428
CAMK1G / calcium/calmodulin dependent protein kinase IG / Q91VB2* / Q96NX5* / Calcium/calmodulin-dependent protein kinase type 1G *ENSGALG0000000131927
PSKH1 / protein serine kinase H1 / P11801* / Q91YA2*ENSGALG0000000164723
CAMKV / CaM kinase like vesicle associated / Q3UHL1* / Q8NCB2* / CaM kinase-like vesicle-associated protein *ENSGALG0000003505822
CAMK1D / calcium/calmodulin dependent protein kinase ID / Q8BW96* / Q8IU85*ENSGALG0000003305121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR017441  Protein kinase, ATP binding site
 IPR020636  Calcium/calmodulin-dependent/calcium-dependent protein kinase
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0038166 angiotensin-activated signaling pathway IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0046928 regulation of neurotransmitter secretion IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0035254 glutamate receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Ca2+ pathway
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Interferon gamma signaling
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000314 NEFL / neurofilament light / P07196* / P08551* / Neurofilament light polypeptide *  / complex / reaction
 ENSGALG00000004083 GRIA1 / glutamate ionotropic receptor AMPA type subunit 1 / P23818* / P42261* / Glutamate receptor 1 *  / reaction
 ENSGALG00000009903 IFNG / P49708 / Interferon gamma / P01579* / P01580*  / reaction
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / complex / reaction
 ENSGALG00000007278 GRIN2A / glutamate ionotropic receptor NMDA type subunit 2A / P35436* / Q12879* / Glutamate receptor ionotropic, NMDA 2A *  / complex / reaction
 ENSGALG00000005621 CAMK2A / calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798* / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction / complex
 ENSGALG00000015598 RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2 / O14827* / ras-specific guanine nucleotide-releasing factor 2 *  / reaction / complex
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / complex / reaction
 ENSGALG00000027415 GRIN2C / glutamate ionotropic receptor NMDA type subunit 2C / Q01098* / Q14957* / Glutamate receptor ionotropic, NMDA 2C *  / complex / reaction
 ENSGALG00000008494 CREB1 / P16220* / Q01147* / cAMP responsive element binding protein 1* / Cyclic AMP-responsive element-binding protein 1 *  / reaction
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / reaction
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / reaction
 ENSGALG00000014463 ACTN2 / P20111 / Alpha-actinin-2 / P35609* / Q9JI91* / actinin alpha 2*  / complex / reaction
 ENSGALG00000038995 GRIA4 / glutamate receptor 4 isoform 1 precursor / P48058* / Q9Z2W8* / glutamate receptor, ionotropic, AMPA4 (alpha 4)* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSGALG00000040724 AKAP9 / A-kinase anchoring protein 9 / Q99996*  / complex / reaction






 

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