ENSGALG00000015598


Gallus gallus

Features
Gene ID: ENSGALG00000015598
  
Biological name :RASGRF2
  
Synonyms : RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2
  
Possible biological names infered from orthology : O14827 / ras-specific guanine nucleotide-releasing factor 2
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 63782412
Gene end: 63904890
  
Corresponding Affymetrix probe sets: Gga.16331.1.S1_at (Chicken Array)   GgaAffx.9947.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000025104
NCBI entrez gene - 100859132     See in Manteia.
RefSeq - XM_004949460
RefSeq - XM_015280709
RefSeq - XM_015280710
RefSeq - XM_015280711
RefSeq - XM_003643077
swissprot - F1ND09
Ensembl - ENSGALG00000015598
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2CEA7ENSDARG00000002816Danio rerio
 rasgrf2aENSDARG00000075054Danio rerio
 O14827ENSG00000113319Homo sapiens
 Rasgrf2ENSMUSG00000021708Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1 / P27671* / Q13972*ENSGALG0000000826263
SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *ENSGALG0000003945013
SOS2 / SOS Ras/Rho guanine nucleotide exchange factor 2 / Q02384* / Q07890* / Son of sevenless homolog 2 *ENSGALG0000001227313
RAPGEF1 / Rap guanine nucleotide exchange factor 1 / Q13905* / Rap guanine nucleotide exchange factor (GEF) 1*ENSGALG0000000371212
RGL4* / RGL2* / Q12967* / Q61193* / RALGDS* / Q8IZJ4* / O15211* / Q03385* / AL162417.1* / ral guanine nucleotide dissociation stimulator* / ral guanine nucleotide dissociation stimulator li...ENSGALG0000000341211
RGL1 / ral guanine nucleotide dissociation stimulator like 1 / Q60695* / Q9NZL6* / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA.*ENSGALG0000000472810
RALGPS1 / Ral GEF with PH domain and SH3 binding motif 1 / A2AR50* / Q5JS13* / Ras-specific guanine nucleotide-releasing factor RalGPS1 *ENSGALG000000009067
Q5ZJK0 / RALGPS2 / Ras-specific guanine nucleotide-releasing factor RalGPS1 / Q9ERD6* / Q86X27* / Ral GEF with PH domain and SH3 binding motif 2*ENSGALG000000042736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR030744  Ras-specific guanine nucleotide-releasing factor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0046578 regulation of Ras protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000314 NEFL / neurofilament light / P07196* / P08551* / Neurofilament light polypeptide *  / complex / reaction
 ENSGALG00000005621 CAMK2A / calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798* / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / complex / reaction
 ENSGALG00000007278 GRIN2A / glutamate ionotropic receptor NMDA type subunit 2A / P35436* / Q12879* / Glutamate receptor ionotropic, NMDA 2A *  / reaction / complex
 ENSGALG00000014463 ACTN2 / P20111 / Alpha-actinin-2 / P35609* / Q9JI91* / actinin alpha 2*  / reaction / complex
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000015598 RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2 / O14827* / ras-specific guanine nucleotide-releasing factor 2 *  / complex
 ENSGALG00000027415 GRIN2C / glutamate ionotropic receptor NMDA type subunit 2C / Q01098* / Q14957* / Glutamate receptor ionotropic, NMDA 2C *  / reaction / complex
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / complex / reaction
 ENSGALG00000040724 AKAP9 / A-kinase anchoring protein 9 / Q99996*  / reaction / complex






 

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