ENSGALG00000008262


Gallus gallus

Features
Gene ID: ENSGALG00000008262
  
Biological name :RASGRF1
  
Synonyms : RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1
  
Possible biological names infered from orthology : P27671 / Q13972
  
Species: Gallus gallus
  
Chr. number: 10
Strand: -1
Band:
Gene start: 19957526
Gene end: 19975760
  
Corresponding Affymetrix probe sets: GgaAffx.2066.1.S1_at (Chicken Array)   GgaAffx.5213.1.S1_at (Chicken Array)   GgaAffx.5215.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013428
NCBI entrez gene - 415578     See in Manteia.
RefSeq - XM_003641866
RefSeq - XM_015292195
swissprot - F1P3U7
Ensembl - ENSGALG00000008262
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RASGRF1ENSDARG00000073824Danio rerio
 Q13972ENSG00000058335Homo sapiens
 P27671ENSMUSG00000032356Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2 / O14827* / ras-specific guanine nucleotide-releasing factor 2 *ENSGALG0000001559861
SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *ENSGALG0000003945013
SOS2 / SOS Ras/Rho guanine nucleotide exchange factor 2 / Q02384* / Q07890* / Son of sevenless homolog 2 *ENSGALG0000001227312
RAPGEF1 / Rap guanine nucleotide exchange factor 1 / Q13905* / Rap guanine nucleotide exchange factor (GEF) 1*ENSGALG0000000371212
RGL1 / ral guanine nucleotide dissociation stimulator like 1 / Q60695* / Q9NZL6* / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA.*ENSGALG0000000472810
RGL4* / RGL2* / Q12967* / Q61193* / RALGDS* / Q8IZJ4* / O15211* / Q03385* / AL162417.1* / ral guanine nucleotide dissociation stimulator* / ral guanine nucleotide dissociation stimulator li...ENSGALG0000000341210
RALGPS1 / Ral GEF with PH domain and SH3 binding motif 1 / A2AR50* / Q5JS13* / Ras-specific guanine nucleotide-releasing factor RalGPS1 *ENSGALG000000009067
Q5ZJK0 / RALGPS2 / Ras-specific guanine nucleotide-releasing factor RalGPS1 / Q9ERD6* / Q86X27* / Ral GEF with PH domain and SH3 binding motif 2*ENSGALG000000042736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR030745  Ras-specific guanine nucleotide-releasing factor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035020 regulation of Rac protein signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046578 regulation of Ras protein signal transduction IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:2000310 regulation of NMDA receptor activity IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030426 growth cone IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0035254 glutamate receptor binding IEA


Pathways (from Reactome)
Pathway description
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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