ENSG00000058335


Homo sapiens

Features
Gene ID: ENSG00000058335
  
Biological name :RASGRF1
  
Synonyms : Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q25.1
Gene start: 78959947
Gene end: 79090773
  
Corresponding Affymetrix probe sets: 1554992_at (Human Genome U133 Plus 2.0 Array)   210550_s_at (Human Genome U133 Plus 2.0 Array)   214905_at (Human Genome U133 Plus 2.0 Array)   215688_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378228
Ensembl peptide - ENSP00000405963
Ensembl peptide - ENSP00000452781
NCBI entrez gene - 5923     See in Manteia.
OMIM - 606600
RefSeq - XM_017022459
RefSeq - NM_001145648
RefSeq - NM_002891
RefSeq - NM_153815
RefSeq - XM_017022455
RefSeq - XM_017022456
RefSeq - XM_017022457
RefSeq - XM_017022458
RefSeq - XM_011521866
RefSeq - XM_011521867
RefSeq Peptide - NP_002882
RefSeq Peptide - NP_722522
RefSeq Peptide - NP_001139120
swissprot - Q13972
Ensembl - ENSG00000058335
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RASGRF1ENSDARG00000073824Danio rerio
 RASGRF1ENSGALG00000008262Gallus gallus
 P27671ENSMUSG00000032356Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2ENSG0000011331966
AL162417.1ENSG0000028524513
SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1ENSG0000011590413
SOS2 / Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2ENSG0000010048513
Q12967 / RALGDS / ral guanine nucleotide dissociation stimulatorENSG0000016027113
Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1ENSG0000010726313
RGL1 / Q9NZL6 / ral guanine nucleotide dissociation stimulator like 1ENSG0000014334410
RGL3 / Q3MIN7 / ral guanine nucleotide dissociation stimulator like 3ENSG000002055179
RGL2 / O15211 / ral guanine nucleotide dissociation stimulator like 2ENSG000002374418
RGL4 / Q8IZJ4 / ral guanine nucleotide dissociation stimulator like 4ENSG000001594968
Q5JS13 / RALGPS1 / Ral GEF with PH domain and SH3 binding motif 1ENSG000001368286
Q86X27 / RALGPS2 / Ral GEF with PH domain and SH3 binding motif 2ENSG000001161916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR030745  Ras-specific guanine nucleotide-releasing factor 1
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007616 long-term memory NAS
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0031175 neuron projection development ISS
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0035020 regulation of Rac protein signal transduction ISS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0046578 regulation of Ras protein signal transduction ISS
 biological_processGO:0046579 positive regulation of Ras protein signal transduction TAS
 biological_processGO:0048167 regulation of synaptic plasticity ISS
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0090630 activation of GTPase activity ISS
 biological_processGO:2000310 regulation of NMDA receptor activity IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0043005 neuron projection NAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IMP
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035254 glutamate receptor binding IEA


Pathways (from Reactome)
Pathway description
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113319 O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2  / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / complex / reaction
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / reaction / complex
 ENSG00000033122 LRRC7 / Q96NW7 / leucine rich repeat containing 7  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / reaction / complex
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction / complex
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction / complex
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / complex / reaction
 ENSG00000277586 NEFL / P07196 / neurofilament light  / reaction / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / reaction / complex
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / complex / reaction
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / reaction / complex
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / reaction / complex
 ENSG00000058335 Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1  / complex
 ENSG00000127914 AKAP9 / Q99996 / A-kinase anchoring protein 9  / reaction / complex
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / reaction / complex
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction / complex
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / reaction / complex






 

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