ENSG00000145349


Homo sapiens

Features
Gene ID: ENSG00000145349
  
Biological name :CAMK2D
  
Synonyms : calcium/calmodulin dependent protein kinase II delta / CAMK2D / Q13557
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q26
Gene start: 113451032
Gene end: 113761927
  
Corresponding Affymetrix probe sets: 224994_at (Human Genome U133 Plus 2.0 Array)   225019_at (Human Genome U133 Plus 2.0 Array)   228555_at (Human Genome U133 Plus 2.0 Array)   230749_s_at (Human Genome U133 Plus 2.0 Array)   231793_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423677
Ensembl peptide - ENSP00000423482
Ensembl peptide - ENSP00000423753
Ensembl peptide - ENSP00000425824
Ensembl peptide - ENSP00000424247
Ensembl peptide - ENSP00000424245
Ensembl peptide - ENSP00000296402
Ensembl peptide - ENSP00000339740
Ensembl peptide - ENSP00000369098
Ensembl peptide - ENSP00000378030
Ensembl peptide - ENSP00000378032
Ensembl peptide - ENSP00000422566
NCBI entrez gene - 817     See in Manteia.
OMIM - 607708
RefSeq - XM_017008678
RefSeq - NM_001321572
RefSeq - NM_001321573
RefSeq - NM_001321574
RefSeq - NM_001321575
RefSeq - NM_001321576
RefSeq - NM_001321577
RefSeq - NM_001321578
RefSeq - NM_001321579
RefSeq - NM_001321580
RefSeq - NM_001321581
RefSeq - NM_001321582
RefSeq - NM_001321583
RefSeq - NM_001321584
RefSeq - NM_001321585
RefSeq - NM_001321586
RefSeq - NM_001321587
RefSeq - NM_001321588
RefSeq - NM_001321589
RefSeq - NM_001321590
RefSeq - NM_001321591
RefSeq - NM_172114
RefSeq - NM_172115
RefSeq - NM_172127
RefSeq - NM_172128
RefSeq - NM_172129
RefSeq - XM_005263253
RefSeq - XM_005263254
RefSeq - XM_006714330
RefSeq - XM_011532289
RefSeq - XM_011532290
RefSeq - XM_011532291
RefSeq - XM_011532292
RefSeq - XM_011532295
RefSeq - XM_017008672
RefSeq - XM_017008673
RefSeq - XM_017008674
RefSeq - XM_017008675
RefSeq - XM_017008676
RefSeq - XM_017008677
RefSeq - NM_001221
RefSeq - NM_001321566
RefSeq - NM_001321567
RefSeq - NM_001321568
RefSeq - NM_001321569
RefSeq - NM_001321570
RefSeq - NM_001321571
RefSeq Peptide - NP_001308495
RefSeq Peptide - NP_001308520
RefSeq Peptide - NP_742112
RefSeq Peptide - NP_742113
RefSeq Peptide - NP_742125
RefSeq Peptide - NP_742126
RefSeq Peptide - NP_742127
RefSeq Peptide - NP_001212
RefSeq Peptide - NP_001308496
RefSeq Peptide - NP_001308497
RefSeq Peptide - NP_001308498
RefSeq Peptide - NP_001308499
RefSeq Peptide - NP_001308500
RefSeq Peptide - NP_001308501
RefSeq Peptide - NP_001308502
RefSeq Peptide - NP_001308503
RefSeq Peptide - NP_001308504
RefSeq Peptide - NP_001308505
RefSeq Peptide - NP_001308506
RefSeq Peptide - NP_001308507
RefSeq Peptide - NP_001308508
RefSeq Peptide - NP_001308509
RefSeq Peptide - NP_001308510
RefSeq Peptide - NP_001308511
RefSeq Peptide - NP_001308512
RefSeq Peptide - NP_001308513
RefSeq Peptide - NP_001308514
RefSeq Peptide - NP_001308515
RefSeq Peptide - NP_001308516
RefSeq Peptide - NP_001308517
RefSeq Peptide - NP_001308518
RefSeq Peptide - NP_001308519
swissprot - E9PBG7
swissprot - D6R938
swissprot - H0Y9C2
swissprot - H0Y9J2
swissprot - Q13557
swissprot - A0A024RDK3
swissprot - E9PF82
Ensembl - ENSG00000145349
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6DEH3ENSDARG00000043010Danio rerio
 CAMK2DENSGALG00000041635Gallus gallus
 Camk2dENSMUSG00000053819Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II betaENSG0000005840484
CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gammaENSG0000014866082
CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alphaENSG0000007080879
CAMK4 / Q16566 / calcium/calmodulin dependent protein kinase IVENSG0000015249528
CAMK1G / Q96NX5 / calcium/calmodulin dependent protein kinase IGENSG0000000811827
CAMK1D / Q8IU85 / calcium/calmodulin dependent protein kinase IDENSG0000018304925
CAMK1 / Q14012 / calcium/calmodulin dependent protein kinase IENSG0000013407225
PNCK / Q6P2M8 / pregnancy up-regulated nonubiquitous CaM kinaseENSG0000013082225
CAMKV / Q8NCB2 / CaM kinase like vesicle associatedENSG0000016407623
PSKH1 / P11801 / protein serine kinase H1ENSG0000015979222
PSKH2 / Q96QS6 / protein serine kinase H2ENSG0000014761320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR017441  Protein kinase, ATP binding site
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002026 regulation of the force of heart contraction TAS
 biological_processGO:0003254 regulation of membrane depolarization IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0008016 regulation of heart contraction TAS
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IMP
 biological_processGO:0010649 regulation of cell communication by electrical coupling ISS
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process ISS
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0030007 cellular potassium ion homeostasis IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis ISS
 biological_processGO:0035022 positive regulation of Rac protein signal transduction IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0055119 relaxation of cardiac muscle ISS
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity TAS
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060341 regulation of cellular localization IMP
 biological_processGO:0061049 cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071277 cellular response to calcium ion TAS
 biological_processGO:0086003 cardiac muscle cell contraction ISS
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IC
 biological_processGO:0098901 regulation of cardiac muscle cell action potential ISS
 biological_processGO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction IC
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1901725 regulation of histone deacetylase activity TAS
 biological_processGO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction IC
 biological_processGO:1901897 regulation of relaxation of cardiac muscle IDA
 biological_processGO:1902306 negative regulation of sodium ion transmembrane transport IDA
 biological_processGO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0034704 calcium channel complex ISS
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IDA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019871 sodium channel inhibitor activity IDA
 molecular_functionGO:0031432 titin binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0044325 ion channel binding ISS
 molecular_functionGO:0050998 nitric-oxide synthase binding IEA


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Interferon gamma signaling
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000033122 LRRC7 / Q96NW7 / leucine rich repeat containing 7  / reaction / complex
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction / complex
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / reaction / complex
 ENSG00000113319 O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2  / complex / reaction
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction / complex
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / reaction / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / reaction / complex
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / reaction / complex
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / complex / reaction
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex / reaction
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000126458 RRAS / P10301 / RAS related  / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000159128 IFNGR2 / P38484 / interferon gamma receptor 2  / reaction
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / complex / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / complex / reaction
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / complex / reaction
 ENSG00000127914 AKAP9 / Q99996 / A-kinase anchoring protein 9  / complex / reaction
 ENSG00000111537 IFNG / P01579 / interferon gamma  / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex / reaction
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / complex / reaction
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / reaction
 ENSG00000277586 NEFL / P07196 / neurofilament light  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction
 ENSG00000027697 IFNGR1 / P15260 / interferon gamma receptor 1  / reaction
 ENSG00000058335 Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1  / reaction / complex
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction






 

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