ENSG00000111537


Homo sapiens

Features
Gene ID: ENSG00000111537
  
Biological name :IFNG
  
Synonyms : IFNG / interferon gamma / P01579
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q15
Gene start: 68154768
Gene end: 68159747
  
Corresponding Affymetrix probe sets: 210354_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000229135
NCBI entrez gene - 3458     See in Manteia.
OMIM - 147570
RefSeq - NM_000619
RefSeq Peptide - NP_000610
swissprot - P01579
Ensembl - ENSG00000111537
  
Related genetic diseases (OMIM): 609135 - {Aplastic anemia}, 609135
  609423 - {AIDS, rapid progression to}, 609423
  609532 - {Hepatitis C virus, response to therapy of}, 609532
  613254 - {TSC2 angiomyolipomas, renal, modifier of}, 613254
  607948 - {Tuberculosis, protection against}, 607948
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IFNGENSGALG00000009903Gallus gallus
 IfngENSMUSG00000055170Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002069  Interferon gamma
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IDA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0006915 apoptotic process IGI
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006959 humoral immune response IBA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010508 positive regulation of autophagy IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0010634 positive regulation of epithelial cell migration IDA
 biological_processGO:0010835 regulation of protein ADP-ribosylation IDA
 biological_processGO:0030857 negative regulation of epithelial cell differentiation ISS
 biological_processGO:0031334 positive regulation of protein complex assembly IDA
 biological_processGO:0032700 negative regulation of interleukin-17 production IDA
 biological_processGO:0032735 positive regulation of interleukin-12 production IDA
 biological_processGO:0032747 positive regulation of interleukin-23 production IDA
 biological_processGO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response IDA
 biological_processGO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein IDA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IDA
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IDA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0045589 regulation of regulatory T cell differentiation TAS
 biological_processGO:0045672 positive regulation of osteoclast differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IDA
 biological_processGO:0050796 regulation of insulin secretion IDA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051712 positive regulation of killing of cells of other organism IDA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway IDA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060550 positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity IDA
 biological_processGO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process IDA
 biological_processGO:0060557 positive regulation of vitamin D biosynthetic process IDA
 biological_processGO:0060559 positive regulation of calcidiol 1-monooxygenase activity IDA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IDA
 biological_processGO:0090312 positive regulation of protein deacetylation IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane HDA
 biological_processGO:1903543 positive regulation of exosomal secretion HDA
 biological_processGO:1904798 positive regulation of core promoter binding IDA
 biological_processGO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005133 interferon-gamma receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interferon gamma signaling
Regulation of IFNG signaling
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000111537 IFNG / P01579 / interferon gamma  / complex
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction
 ENSG00000159128 IFNGR2 / P38484 / interferon gamma receptor 2  / reaction / complex
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction
 ENSG00000163932 PRKCD / Q05655 / protein kinase C delta  / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction / complex
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / reaction / complex
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction
 ENSG00000027697 IFNGR1 / P15260 / interferon gamma receptor 1  / complex / reaction
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction






 

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