ENSG00000185338


Homo sapiens

Features
Gene ID: ENSG00000185338
  
Biological name :SOCS1
  
Synonyms : O15524 / SOCS1 / suppressor of cytokine signaling 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.13
Gene start: 11254405
Gene end: 11256200
  
Corresponding Affymetrix probe sets: 209999_x_at (Human Genome U133 Plus 2.0 Array)   210000_s_at (Human Genome U133 Plus 2.0 Array)   210001_s_at (Human Genome U133 Plus 2.0 Array)   213337_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000329418
Ensembl peptide - ENSP00000496577
NCBI entrez gene - 8651     See in Manteia.
OMIM - 603597
RefSeq - NM_003745
RefSeq Peptide - NP_003736
swissprot - O15524
swissprot - Q4JHT5
Ensembl - ENSG00000185338
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs1aENSDARG00000038095Danio rerio
 SOCS1ENSGALG00000007158Gallus gallus
 Socs1ENSMUSG00000038037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CISH / Q9NSE2 / cytokine inducible SH2 containing proteinENSG0000011473729
SOCS3 / O14543 / suppressor of cytokine signaling 3ENSG0000018455728
SOCS2 / O14508 / suppressor of cytokine signaling 2ENSG0000012083327
SOCS7 / O14512 / suppressor of cytokine signaling 7ENSG0000027421124
SOCS6 / O14544 / suppressor of cytokine signaling 6ENSG0000017067723
SOCS4 / Q8WXH5 / suppressor of cytokine signaling 4ENSG0000018000821
SOCS5 / O75159 / suppressor of cytokine signaling 5ENSG0000017115021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028411  Suppressor of cytokine signalling 1
 IPR035861  SOCS1, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation ISS
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway ISS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038111 interleukin-7-mediated signaling pathway TAS
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein ISS
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway ISS
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 molecular_functionGO:0004860 protein kinase inhibitor activity TAS
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019210 kinase inhibitor activity ISS
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
Regulation of KIT signaling
MyD88:Mal cascade initiated on plasma membrane
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000049130 KITLG / P21583 / KIT ligand  / complex / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000142166 IFNAR1 / P17181 / interferon alpha and beta receptor subunit 1  / complex / reaction
 ENSG00000154582 ELOC / Q15369 / elongin C  / complex
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / complex / reaction
 ENSG00000111537 IFNG / P01579 / interferon gamma  / complex / reaction
 ENSG00000166266 CUL5 / Q93034 / cullin 5  / complex
 ENSG00000112964 GHR / P10912 / growth hormone receptor  / complex / reaction
 ENSG00000103363 ELOB / Q15370 / elongin B  / complex
 ENSG00000171855 IFNB1 / P01574 / interferon beta 1  / reaction / complex
 ENSG00000159110 IFNAR2 / P48551 / interferon alpha and beta receptor subunit 2  / reaction / complex
 ENSG00000027697 IFNGR1 / P15260 / interferon gamma receptor 1  / reaction / complex
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction / complex
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000159128 IFNGR2 / P38484 / interferon gamma receptor 2  / reaction / complex
 ENSG00000170581 STAT2 / P52630 / signal transducer and activator of transcription 2  / complex / reaction






 

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