ENSG00000180008


Homo sapiens

Features
Gene ID: ENSG00000180008
  
Biological name :SOCS4
  
Synonyms : Q8WXH5 / SOCS4 / suppressor of cytokine signaling 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q22.3
Gene start: 55027230
Gene end: 55049488
  
Corresponding Affymetrix probe sets: 1552792_at (Human Genome U133 Plus 2.0 Array)   226178_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341327
Ensembl peptide - ENSP00000378855
Ensembl peptide - ENSP00000452522
NCBI entrez gene - 122809     See in Manteia.
OMIM - 616337
RefSeq - XM_011536426
RefSeq - NM_080867
RefSeq - NM_199421
RefSeq - XM_011536425
RefSeq Peptide - NP_543143
RefSeq Peptide - NP_955453
swissprot - Q5H9R6
swissprot - Q8WXH5
Ensembl - ENSG00000180008
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SOCS4ENSGALG00000012179Gallus gallus
 Socs4ENSMUSG00000048379Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOCS5 / O75159 / suppressor of cytokine signaling 5ENSG0000017115054
SOCS6 / O14544 / suppressor of cytokine signaling 6ENSG0000017067722
SOCS7 / O14512 / suppressor of cytokine signaling 7ENSG0000027421119
CISH / Q9NSE2 / cytokine inducible SH2 containing proteinENSG0000011473714
SOCS2 / O14508 / suppressor of cytokine signaling 2ENSG0000012083312
SOCS3 / O14543 / suppressor of cytokine signaling 3ENSG0000018455711
SOCS1 / O15524 / suppressor of cytokine signaling 1ENSG0000018533810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR022252  SOCS4/SOCS5 domain
 IPR028416  Suppressor of cytokine signalling 4
 IPR035864  SOCS4, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily
 IPR037342  SOCS4, SOCS box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IDA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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