ENSG00000120833


Homo sapiens

Features
Gene ID: ENSG00000120833
  
Biological name :SOCS2
  
Synonyms : O14508 / SOCS2 / suppressor of cytokine signaling 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q22
Gene start: 93569814
Gene end: 93583487
  
Corresponding Affymetrix probe sets: 203372_s_at (Human Genome U133 Plus 2.0 Array)   203373_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474888
Ensembl peptide - ENSP00000474805
Ensembl peptide - ENSP00000481249
Ensembl peptide - ENSP00000339428
Ensembl peptide - ENSP00000442898
Ensembl peptide - ENSP00000447161
Ensembl peptide - ENSP00000447902
Ensembl peptide - ENSP00000448611
Ensembl peptide - ENSP00000448709
Ensembl peptide - ENSP00000448815
Ensembl peptide - ENSP00000449227
Ensembl peptide - ENSP00000473902
NCBI entrez gene - 8835     See in Manteia.
OMIM - 605117
RefSeq - XM_017020156
RefSeq - NM_003877
RefSeq - XM_011538929
RefSeq - XM_011538935
RefSeq - XM_011538936
RefSeq - XM_017020147
RefSeq - XM_017020148
RefSeq - XM_017020149
RefSeq - XM_017020150
RefSeq - XM_017020151
RefSeq - XM_017020152
RefSeq - XM_017020153
RefSeq - XM_017020154
RefSeq - XM_017020155
RefSeq - NM_001270467
RefSeq - NM_001270468
RefSeq - NM_001270469
RefSeq - NM_001270470
RefSeq - NM_001270471
RefSeq Peptide - NP_001257400
RefSeq Peptide - NP_003868
RefSeq Peptide - NP_001257396
RefSeq Peptide - NP_001257397
RefSeq Peptide - NP_001257398
RefSeq Peptide - NP_001257399
swissprot - A0A024RBD2
swissprot - S4R3W1
swissprot - F8VS53
swissprot - F8VU91
swissprot - O14508
swissprot - F8VRV3
swissprot - S4R3Z4
Ensembl - ENSG00000120833
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs2ENSDARG00000045557Danio rerio
 SOCS2ENSGALG00000011295Gallus gallus
 Socs2ENSMUSG00000020027Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CISH / Q9NSE2 / cytokine inducible SH2 containing proteinENSG0000011473744
SOCS6 / O14544 / suppressor of cytokine signaling 6ENSG0000017067732
SOCS3 / O14543 / suppressor of cytokine signaling 3ENSG0000018455730
SOCS1 / O15524 / suppressor of cytokine signaling 1ENSG0000018533829
SOCS5 / O75159 / suppressor of cytokine signaling 5ENSG0000017115029
SOCS7 / O14512 / suppressor of cytokine signaling 7ENSG0000027421129
SOCS4 / Q8WXH5 / suppressor of cytokine signaling 4ENSG0000018000827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028410  Suppressor of cytokine signalling 2
 IPR035862  SOCS2, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0007595 lactation IEA
 biological_processGO:0009966 regulation of signal transduction NAS
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0032355 response to estradiol IDA
 biological_processGO:0032870 cellular response to hormone stimulus IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038111 interleukin-7-mediated signaling pathway TAS
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0040015 negative regulation of multicellular organism growth IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 biological_processGO:0060396 growth hormone receptor signaling pathway IDA
 biological_processGO:0060749 mammary gland alveolus development IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005131 growth hormone receptor binding NAS
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008269 JAK pathway signal transduction adaptor activity TAS


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
Neddylation
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / reaction / complex
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / complex / reaction
 ENSG00000112964 GHR / P10912 / growth hormone receptor  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex






 

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