ENSG00000170677


Homo sapiens

Features
Gene ID: ENSG00000170677
  
Biological name :SOCS6
  
Synonyms : O14544 / SOCS6 / suppressor of cytokine signaling 6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q22.2
Gene start: 70288901
Gene end: 70330200
  
Corresponding Affymetrix probe sets: 206020_at (Human Genome U133 Plus 2.0 Array)   214462_at (Human Genome U133 Plus 2.0 Array)   227542_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463395
Ensembl peptide - ENSP00000381034
Ensembl peptide - ENSP00000463064
NCBI entrez gene - 9306     See in Manteia.
OMIM - 605118
RefSeq - XM_017026087
RefSeq - NM_004232
RefSeq - XM_005266783
RefSeq - XM_017026086
RefSeq Peptide - NP_004223
swissprot - O14544
swissprot - J3KTM7
swissprot - A0A024R379
Ensembl - ENSG00000170677
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs6aENSDARG00000058565Danio rerio
 SOCS6ENSGALG00000013731Gallus gallus
 Socs6ENSMUSG00000056153Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOCS7 / O14512 / suppressor of cytokine signaling 7ENSG0000027421124
SOCS5 / O75159 / suppressor of cytokine signaling 5ENSG0000017115021
SOCS4 / Q8WXH5 / suppressor of cytokine signaling 4ENSG0000018000818
CISH / Q9NSE2 / cytokine inducible SH2 containing proteinENSG0000011473713
SOCS2 / O14508 / suppressor of cytokine signaling 2ENSG0000012083312
SOCS3 / O14543 / suppressor of cytokine signaling 3ENSG0000018455710
SOCS1 / O15524 / suppressor of cytokine signaling 1ENSG000001853389


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028421  Suppressor of cytokine signalling 6
 IPR035865  SOCS6, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily
 IPR037345  SOCS6, SOCS box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0006952 defense response TAS
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010498 proteasomal protein catabolic process IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of KIT signaling
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000049130 KITLG / P21583 / KIT ligand  / reaction / complex






 

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