ENSMUSG00000056153


Mus musculus

Features
Gene ID: ENSMUSG00000056153
  
Biological name :Socs6
  
Synonyms : Q9JLY0 / Socs6 / Suppressor of cytokine signaling 6
  
Possible biological names infered from orthology : O14544
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E4
Gene start: 88665224
Gene end: 88927481
  
Corresponding Affymetrix probe sets: 10460118 (MoGene1.0st)   10566668 (MoGene1.0st)   1435492_at (Mouse Genome 430 2.0 Array)   1450129_a_at (Mouse Genome 430 2.0 Array)   1452764_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116148
Ensembl peptide - ENSMUSP00000122237
Ensembl peptide - ENSMUSP00000118764
Ensembl peptide - ENSMUSP00000064929
Ensembl peptide - ENSMUSP00000114993
NCBI entrez gene - 54607     See in Manteia.
MGI - MGI:1924885
RefSeq - XM_006526513
RefSeq - XM_011247090
RefSeq - NM_018821
RefSeq - XM_011247089
RefSeq Peptide - NP_061291
swissprot - Q9JLY0
swissprot - D3Z776
swissprot - A0A1C7ZMY9
Ensembl - ENSMUSG00000056153
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs6aENSDARG00000058565Danio rerio
 SOCS6ENSGALG00000013731Gallus gallus
 SOCS6ENSG00000170677Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Socs7 / Q8VHQ2 / Suppressor of cytokine signaling 7 / O14512*ENSMUSG0000003848523
Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*ENSMUSG0000003710420
Socs4 / Q91ZA6 / Suppressor of cytokine signaling 4 / Q8WXH5*ENSMUSG0000004837917
Cish / Q62225 / Cytokine-inducible SH2-containing protein / Q9NSE2*ENSMUSG0000003257812
Socs2 / O35717 / suppressor of cytokine signaling 2 / O14508*ENSMUSG0000002002711
Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*ENSMUSG000000531139
Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*ENSMUSG000000380379


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028421  Suppressor of cytokine signalling 6
 IPR035865  SOCS6, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily
 IPR037345  SOCS6, SOCS box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010498 proteasomal protein catabolic process ISO
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050868 negative regulation of T cell activation IDA
 cellular_componentGO:0001772 immunological synapse ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex






 

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