ENSMUSG00000032578


Mus musculus

Features
Gene ID: ENSMUSG00000032578
  
Biological name :Cish
  
Synonyms : Cish / Cytokine-inducible SH2-containing protein / Q62225
  
Possible biological names infered from orthology : Q9NSE2
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 107296026
Gene end: 107302784
  
Corresponding Affymetrix probe sets: 10588577 (MoGene1.0st)   1448724_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127523
Ensembl peptide - ENSMUSP00000129941
Ensembl peptide - ENSMUSP00000082183
NCBI entrez gene - 12700     See in Manteia.
MGI - MGI:103159
RefSeq - NM_009895
RefSeq - NM_001317354
RefSeq Peptide - NP_001304283
RefSeq Peptide - NP_034025
swissprot - Q62225
swissprot - E9Q2F4
swissprot - E9Q273
Ensembl - ENSMUSG00000032578
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cishENSDARG00000060316Danio rerio
 cishbENSDARG00000016773Danio rerio
 CISHENSGALG00000002260Gallus gallus
 CISHENSG00000114737Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Socs2 / O35717 / suppressor of cytokine signaling 2 / O14508*ENSMUSG0000002002733
Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*ENSMUSG0000005311327
Socs7 / Q8VHQ2 / Suppressor of cytokine signaling 7 / O14512*ENSMUSG0000003848525
Socs6 / Q9JLY0 / Suppressor of cytokine signaling 6 / O14544*ENSMUSG0000005615325
Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*ENSMUSG0000003803724
Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*ENSMUSG0000003710423
Socs4 / Q91ZA6 / Suppressor of cytokine signaling 4 / Q8WXH5*ENSMUSG0000004837923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028425  Cytokine-inducible SH2-containing protein
 IPR035887  CIS, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0002281 abnormal respiratory mucosa goblet cell morphology "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

 MP:0008711 increased interleukin-9 secretion "increase in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
Show

Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon
Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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