ENSMUSG00000048379


Mus musculus

Features
Gene ID: ENSMUSG00000048379
  
Biological name :Socs4
  
Synonyms : Q91ZA6 / Socs4 / Suppressor of cytokine signaling 4
  
Possible biological names infered from orthology : Q8WXH5
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C1
Gene start: 47276931
Gene end: 47296102
  
Corresponding Affymetrix probe sets: 10414350 (MoGene1.0st)   1421273_at (Mouse Genome 430 2.0 Array)   1421274_at (Mouse Genome 430 2.0 Array)   1421275_s_at (Mouse Genome 430 2.0 Array)   1455142_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066031
Ensembl peptide - ENSMUSP00000154000
NCBI entrez gene - 67296     See in Manteia.
MGI - MGI:1914546
RefSeq - NM_080843
RefSeq Peptide - NP_543119
swissprot - Q91ZA6
Ensembl - ENSMUSG00000048379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SOCS4ENSGALG00000012179Gallus gallus
 SOCS4ENSG00000180008Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*ENSMUSG0000003710452
Socs6 / Q9JLY0 / Suppressor of cytokine signaling 6 / O14544*ENSMUSG0000005615320
Socs7 / Q8VHQ2 / Suppressor of cytokine signaling 7 / O14512*ENSMUSG0000003848519
Cish / Q62225 / Cytokine-inducible SH2-containing protein / Q9NSE2*ENSMUSG0000003257814
Socs2 / O35717 / suppressor of cytokine signaling 2 / O14508*ENSMUSG0000002002712
Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*ENSMUSG0000005311311
Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*ENSMUSG0000003803710


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR022252  SOCS4/SOCS5 domain
 IPR028416  Suppressor of cytokine signalling 4
 IPR035864  SOCS4, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily
 IPR037342  SOCS4, SOCS box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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