ENSMUSG00000038037


Mus musculus

Features
Gene ID: ENSMUSG00000038037
  
Biological name :Socs1
  
Synonyms : O35716 / Socs1 / Suppressor of cytokine signaling 1
  
Possible biological names infered from orthology : O15524
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 10782240
Gene end: 10785536
  
Corresponding Affymetrix probe sets: 10437668 (MoGene1.0st)   1440047_at (Mouse Genome 430 2.0 Array)   1450446_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038121
Ensembl peptide - ENSMUSP00000155530
NCBI entrez gene - 12703     See in Manteia.
MGI - MGI:1354910
RefSeq - NM_001271603
RefSeq - NM_009896
RefSeq Peptide - NP_001258532
RefSeq Peptide - NP_034026
swissprot - O35716
Ensembl - ENSMUSG00000038037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs1aENSDARG00000038095Danio rerio
 SOCS1ENSGALG00000007158Gallus gallus
 SOCS1ENSG00000185338Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cish / Q62225 / Cytokine-inducible SH2-containing protein / Q9NSE2*ENSMUSG0000003257829
Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*ENSMUSG0000005311327
Socs2 / O35717 / suppressor of cytokine signaling 2 / O14508*ENSMUSG0000002002726
Socs7 / Q8VHQ2 / Suppressor of cytokine signaling 7 / O14512*ENSMUSG0000003848524
Socs6 / Q9JLY0 / Suppressor of cytokine signaling 6 / O14544*ENSMUSG0000005615324
Socs4 / Q91ZA6 / Suppressor of cytokine signaling 4 / Q8WXH5*ENSMUSG0000004837920
Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*ENSMUSG0000003710420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028411  Suppressor of cytokine signalling 1
 IPR035861  SOCS1, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IDA
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007259 JAK-STAT cascade IDA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010533 regulation of activation of Janus kinase activity IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042509 regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation ISO
 biological_processGO:0046425 regulation of JAK-STAT cascade IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade ISO
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IDA
 biological_processGO:0050707 regulation of cytokine secretion IMP
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071345 cellular response to cytokine stimulus ISO
 biological_processGO:0071407 cellular response to organic cyclic compound ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule ISO
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019210 kinase inhibitor activity IDA
 molecular_functionGO:0019901 protein kinase binding ISO


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
Interferon alpha/beta signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish
Genetic Background: B6.129P2-Socs1tm1Kish

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Foxp3tm1.1Ayr/Foxp3tm1.1Ayr,Mir146tm1.1Bal/Mir146tm1.1Bal
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Siglecgtm1Yliu/Siglecgtm1Yliu
Genetic Background: C57BL/6-Siglecgtm1Yliu

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish
Genetic Background: B6.129P2-Socs1tm1Kish

 MP:0001313 increased incidence of corneal inflammation "greater than average and persistent occurrence of corneal irritation" [J:4606]
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Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish
Genetic Background: B6.129P2-Socs1tm1Kish

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Socs1tm3.1Wehi/Socs1tm3.1Wehi
Genetic Background: C57BL/6-Socs1tm3.1Wehi

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish
Genetic Background: B6.129P2-Socs1tm1Kish

Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001884 mammary alveolar hyperplasia 
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Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

Allelic Composition: Ifngtm1Ts/Ifng+,Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm3Wehi,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1atm1.1Ehess/Cacna1atm1.1Ehess
Genetic Background: C57BL/6-Cacna1atm1.1Ehess

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish
Genetic Background: B6.129P2-Socs1tm1Kish

Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm3Wehi,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish
Genetic Background: B6.129P2-Socs1tm1Kish

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Socs1tm1.1Ayr/Socs1tm1.1Ayr
Genetic Background: involves: C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Socs1tm1Wehi/Socs1tm3Wehi,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish
Genetic Background: B6.129P2-Socs1tm1Kish

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish
Genetic Background: B6.129P2-Socs1tm1Kish

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Wehi/Socs1tm3Wehi,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Socs1tm1Wehi/Socs1tm3Wehi,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Wehi/Socs1tm3Wehi,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0008171 abnormal mature B cell morphology "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008172 abnormal follicular B cell morphology "any structural anomaly of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Socs1tm2Wehi/Socs1tm2Wehi
Genetic Background: C57BL/6-Socs1tm2Wehi

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Socs1tm3.1Wehi/Socs1tm3.1Wehi
Genetic Background: C57BL/6-Socs1tm3.1Wehi

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifng+,Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

 MP:0010903 abnormal pulmonary alveolus wall morphology 
Show

Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Socs1tm1Jni/Socs1tm1Jni
Genetic Background: Not Specified

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish
Genetic Background: B6.129P2-Socs1tm1Kish

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Socs1tm3.1Wehi/Socs1tm3.1Wehi
Genetic Background: C57BL/6-Socs1tm3.1Wehi

 MP:0013585 thymus cortex atrophy "acquired diminution of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
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Allelic Composition: Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0013590 enlarged thymus medulla "increased size of the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Socs1tm1Wehi/Socs1tm3Wehi,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0013741 absent thymus corticomedullary boundary " complete absence or loss of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; normally, this is the site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:Anna, PMID:17067941]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0013771 decreased effector memory T-helper cell number "reduction in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [MGI:Saran]
Show

Allelic Composition: Socs1tm1.1Ayr/Socs1tm1.1Ayr
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / complex / reaction
 ENSMUSG00000022967 Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / complex / reaction
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / reaction / complex
 ENSMUSG00000048806 Ifnb1 / P01575 / interferon beta 1, fibroblast / P01574* / interferon beta 1*  / complex / reaction
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / complex
 ENSMUSG00000022971 O35664 / Ifnar2 / interferon (alpha and beta) receptor 2 / P48551* / AP000295.1* / interferon alpha and beta receptor subunit 2*  / complex
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / reaction / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / reaction / complex
 ENSMUSG00000055737 Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*  / complex / reaction
 ENSMUSG00000032030 Cul5 / cullin 5 / Q93034*  / complex
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / complex
 ENSMUSG00000095498 Ifna1 / P01572 / Interferon alpha-1 / IFNA2* / IFNA5* / IFNA4* / IFNA6* / IFNA7* / IFNA8* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566...  / complex / reaction
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / complex






 

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