Manteia - Molecule gene

ENSMUSG00000055737

Mus musculus

Features

Gene ID:	ENSMUSG00000055737

Biological name :	Ghr

Synonyms :	Ghr / Growth hormone receptor Growth hormone-binding protein / P16882

Possible biological names infered from orthology :	growth hormone receptor / P10912

Species:	Mus musculus

Chr. number:	15
Strand:	-1
Band:	A1
Gene start:	3317760
Gene end:	3583492

Corresponding Affymetrix probe sets:	10427402 (MoGene1.0st) 1417962_s_at (Mouse Genome 430 2.0 Array) 1451501_a_at (Mouse Genome 430 2.0 Array) 1451871_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000106325 Ensembl peptide - ENSMUSP00000124064 Ensembl peptide - ENSMUSP00000125044 Ensembl peptide - ENSMUSP00000069457 Ensembl peptide - ENSMUSP00000106326 NCBI entrez gene - 14600 See in Manteia. MGI - MGI:95708 RefSeq - NM_001048178 RefSeq - NM_001286370 RefSeq - NM_010284 RefSeq Peptide - NP_001041643 RefSeq Peptide - NP_001273299 RefSeq Peptide - NP_034414 swissprot - Q3UP14 swissprot - E0CXS6 swissprot - P16882 Ensembl - ENSMUSG00000055737

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ghra	ENSDARG00000054771	Danio rerio
ghrb	ENSDARG00000007671	Danio rerio
GHR	ENSGALG00000014855	Gallus gallus
GHR	ENSG00000112964	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Prlr / Q08501 / prolactin receptor / P16471*	ENSMUSG00000005268	20
Crlf1 / Q9JM58 / Cytokine receptor-like factor 1 / O75462*	ENSMUSG00000007888	9
Gm21973 / PRLR* / P16471* / prolactin receptor*	ENSMUSG00000094814	3

Protein motifs (from Interpro)

Interpro ID	Name
IPR003528	Long hematopoietin receptor, single chain, conserved site
IPR003961	Fibronectin type III
IPR013783	Immunoglobulin-like fold
IPR015152	Growth hormone/erythropoietin receptor, ligand binding
IPR025871	Growth hormone-binding protein
IPR036116	Fibronectin type III superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000187	activation of MAPK activity	IEA
biological_process	GO:0000255	allantoin metabolic process	IMP
biological_process	GO:0006101	citrate metabolic process	IMP
biological_process	GO:0006103	2-oxoglutarate metabolic process	IMP
biological_process	GO:0006105	succinate metabolic process	IMP
biological_process	GO:0006107	oxaloacetate metabolic process	IMP
biological_process	GO:0006549	isoleucine metabolic process	IMP
biological_process	GO:0006573	valine metabolic process	IMP
biological_process	GO:0006600	creatine metabolic process	IMP
biological_process	GO:0006631	fatty acid metabolic process	IMP
biological_process	GO:0006897	endocytosis	IEA
biological_process	GO:0007259	JAK-STAT cascade	IEA
biological_process	GO:0009725	response to hormone	IEA
biological_process	GO:0009755	hormone-mediated signaling pathway	IEA
biological_process	GO:0019221	cytokine-mediated signaling pathway	IEA
biological_process	GO:0019530	taurine metabolic process	IMP
biological_process	GO:0032094	response to food	IEA
biological_process	GO:0032355	response to estradiol	ISO
biological_process	GO:0032869	cellular response to insulin stimulus	IEA
biological_process	GO:0032870	cellular response to hormone stimulus	ISO
biological_process	GO:0034097	response to cytokine	IEA
biological_process	GO:0040014	regulation of multicellular organism growth	IDA
biological_process	GO:0040018	positive regulation of multicellular organism growth	ISO
biological_process	GO:0042976	activation of Janus kinase activity	IEA
biological_process	GO:0043278	response to morphine	IEA
biological_process	GO:0043434	response to peptide hormone	IEA
biological_process	GO:0045597	positive regulation of cell differentiation	IEA
biological_process	GO:0046427	positive regulation of JAK-STAT cascade	IEA
biological_process	GO:0046449	creatinine metabolic process	IMP
biological_process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO
biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA
biological_process	GO:0051384	response to glucocorticoid	IEA
biological_process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	IEA
biological_process	GO:0060396	growth hormone receptor signaling pathway	IDA
biological_process	GO:0060416	response to growth hormone	IEA
biological_process	GO:0070555	response to interleukin-1	IEA
biological_process	GO:1901215	negative regulation of neuron death	IEA
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005615	extracellular space	ISO
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005887	integral component of plasma membrane	ISO
cellular_component	GO:0009986	cell surface	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	ISO
cellular_component	GO:0019898	extrinsic component of membrane	IDA
cellular_component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO
cellular_component	GO:0043025	neuronal cell body	IEA
cellular_component	GO:0043235	receptor complex	ISO
cellular_component	GO:0070195	growth hormone receptor complex	ISO
molecular_function	GO:0004896	cytokine receptor activity	IEA
molecular_function	GO:0004903	growth hormone receptor activity	IDA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0017046	peptide hormone binding	ISO
molecular_function	GO:0019838	growth factor binding	ISO
molecular_function	GO:0019901	protein kinase binding	IEA
molecular_function	GO:0019903	protein phosphatase binding	IEA
molecular_function	GO:0042169	SH2 domain binding	IEA
molecular_function	GO:0042802	identical protein binding	ISO
molecular_function	GO:0042803	protein homodimerization activity	ISO

Pathways (from Reactome)

Pathway description

Prolactin receptor signaling

Growth hormone receptor signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000005	increased brown fat amount	"increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]	Show Allelic Composition: Cd151^tm2Nki/Cd151^tm2Nki,Itga3^tm1Son/Itga3⁺,Krt14^tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151^tm2Nki Itga3^tm1Son Krt14^tm1(cre)Wbm
MP:0000008	increased white fat amount	"increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pik3cd^tm1Jni/Pik3cd^tm1Jni Genetic Background: involves: 129P2/OlaHsd
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Arge/Ghr^tm1Arge,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Arge/Ghr^tm1Arge,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
MP:0000166	abnormal chondrocyte morphology	"anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Arge/Ghr^tm1Arge,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm2Mwat/Ghr^tm2Mwat Genetic Background: involves: 129X1/SvJ * C57BL
MP:0001129	impaired ovarian folliculogenesis	"a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001131	abnormal ovarian follicles	"malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Pik3cd^tm1Jni/Pik3cd^tm1Jni Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ghr^tm1Jjk/Ghr⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001259	abnormal body weight	"anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Pik3cd^tm1Jni/Pik3cd^tm1Jni Genetic Background: involves: 129P2/OlaHsd
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Cd151^tm2Nki/Cd151^tm2Nki,Itga3^tm1Son/Itga3⁺,Krt14^tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151^tm2Nki Itga3^tm1Son Krt14^tm1(cre)Wbm
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Ghr^tm2Mwat/Ghr⁺ Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Ghr^tm1.1Jero/Ghr^tm1.1Jero Genetic Background: B6.129X1-Ghr^tm1.1Jero Allelic Composition: Ghr^tm1.1Jero/Ghr⁺ Genetic Background: B6.129X1-Ghr^tm1.1Jero Allelic Composition: Ghr^m1Btlr/Ghr^m1Btlr Genetic Background: C57BL/6J-Ghr^m1Btlr Allelic Composition: Ghr^m1Btlr/Ghr⁺ Genetic Background: C57BL/6J-Ghr^m1Btlr
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Pik3cd^tm1Jni/Pik3cd^tm1Jni Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ghr^tm1.2Masp/Ghr^tm1.2Masp Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ghr^m1Btlr/Ghr^m1Btlr Genetic Background: C57BL/6J-Ghr^m1Btlr
MP:0001462	abnormal avoidance learning behavior	"defects in the ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Pik3cd^tm1Jni/Pik3cd^tm1Jni Genetic Background: involves: 129P2/OlaHsd
MP:0001554	increased circulating free fatty acid level	"higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Mwat/Ghr^tm1Mwat Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm2Mwat/Ghr^tm2Mwat Genetic Background: involves: 129X1/SvJ * C57BL
MP:0001661	extended life span	"persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001729	impaired implantation	"impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Mwat/Ghr^tm1Mwat Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm1Mwat/Ghr⁺ Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm2Mwat/Ghr^tm2Mwat Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm2Mwat/Ghr⁺ Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1Jjk/Ghr⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Ghr^tm1.2Masp/Ghr^tm1.2Masp Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Ghr^tm1Arge/Ghr^tm1Arge,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
MP:0001745	increased circulating corticosterone level	"greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
MP:0001784	abnormal fluid regulation	"anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd151^tm2Nki/Cd151^tm2Nki,Itga3^tm1Son/Itga3⁺,Krt14^tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151^tm2Nki Itga3^tm1Son Krt14^tm1(cre)Wbm
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001938	delayed sexual maturation	"immaturity of the sexual organs at a given age" [J:61190]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002063	abnormal learning/memory/conditioning	"altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pik3cd^tm1Jni/Pik3cd^tm1Jni Genetic Background: involves: 129P2/OlaHsd
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Bcar3^tm1Lern/Bcar3^tm1Lern Genetic Background: B6.129S6-Bcar3^tm1Lern
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pik3cd^tm1Jni/Pik3cd^tm1Jni Genetic Background: involves: 129P2/OlaHsd
MP:0002175	low brain weight	"lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002176	high brain weight	"greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Mwat/Ghr^tm1Mwat Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm2Mwat/Ghr^tm2Mwat Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1.1Jero/Ghr^tm1.1Jero Genetic Background: B6.129X1-Ghr^tm1.1Jero
MP:0002191	abnormal artery morphology	"malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002293	long gestation period	"increase in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA
MP:0002636	delayed vaginal opening	"the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA
MP:0002680	decreased number of corpora lutea	"fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002696	decreased circulating glucagon level	"lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6 Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002773	decreased circulating luteinizing hormone level	"lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002782	abnormal testicular secretion	"malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0002965	hyperalbuminemia	"blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm2Mwat/Ghr^tm2Mwat Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd
MP:0003019	increased circulating chloride level	"elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0003059	decreased insulin secretion	"less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Twsg1^tm1.1Mboc/Twsg1^tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0003355	reduced ovulation	"reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0003356	impaired lutenization	"atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:57854, J:43075]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm2Mwat/Ghr^tm2Mwat Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Ghr^tm1.1Jero/Ghr^tm1.1Jero Genetic Background: B6.129X1-Ghr^tm1.1Jero
MP:0003409	decreased width of hypertrophic chondrocyte zone	"decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Arge/Ghr^tm1Arge,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Arge/Ghr^tm1Arge,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
MP:0003503	decreased activity of thyroid		Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
MP:0003507	abnormal ovary physiology	"anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0003662	abnormal proliferative zone	"germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Arge/Ghr^tm1Arge,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
MP:0003797	abnormal compact bone morphology	"structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0003917	increased kidney weight	"greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0003918	decreased kidney weight	"reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA
MP:0003949	abnormal circulating lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004201	fetal growth retardation	"slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1.1Jero/Ghr^tm1.1Jero Genetic Background: B6.129X1-Ghr^tm1.1Jero
MP:0004701	decreased circulating insulin-like growth factor I level	"reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Mwat/Ghr^tm1Mwat Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm2Mwat/Ghr^tm2Mwat Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA Allelic Composition: Ghr^tm1.1Jero/Ghr^tm1.1Jero Genetic Background: B6.129X1-Ghr^tm1.1Jero
MP:0004702	increased circulating insulin-like growth factor I level	"increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0004804	decreased susceptibility to autoimmune diabetes	"reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004892	increased adiponectin level	"greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004893	decreased adiponectin level	"reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0004904	increased uterus weight	"increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004908	abnormal seminal gland weight	"anomaly in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004910	decreased seminal gland weight	"reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004920	increased placenta weight	"increase in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004927	abnormal epididymis weight	"anomaly in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004929	decreased epididymis weight	"reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0004962	decreased prostate weight	"reduction in the average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0005123	increased circulating growth hormone level	"greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA Allelic Composition: Ghr^tm1.1Jero/Ghr^tm1.1Jero Genetic Background: B6.129X1-Ghr^tm1.1Jero
MP:0005124	increased circulating prolactin level	"greater than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0005146	decreased circulating VLDL cholesterol level	"less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0005181	decreased circulating estradiol level	"less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA
MP:0005449	abnormal food intake	"anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0005458	increased percent body fat	"more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1.1Jero/Ghr^tm1.1Jero Genetic Background: B6.129X1-Ghr^tm1.1Jero
MP:0005473	decreased triiodothyronine level	"less than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0005478	decreased circulating thyroxine level	"less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
MP:0005479	decreased circulating triiodothyronine level	"less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
MP:0005534	decreased body temperature	"less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Twsg1^tm1.1Mboc/Twsg1^tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6 Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0005669	increased circulating leptin level	"greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0006264	decreased systolic blood pressure	"abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0006380	abnormal spermatid morphology	"anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0008938	decreased pituitary gland weight	"reduction in the average weight of the compound gland suspended from the base of the hypothalamus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0008940	delayed balanopreputial separation	"the separation of the prepuce from the glans penis (balanus), a result of the cornification of the balano-preputial epithelium, occurring at a later than expected age; balanopreputial separation is used as an index for the onset of male puberty and is androgen-sensitive in the rat" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0008974	proportional dwarf	"abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn Genetic Background: involves: 129S4/SvJae Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^tm1Arge/Ghr^tm1Arge,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
MP:0008975	delayed male fertility	"ability of a male organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0008976	delayed female fertility	"ability of a female organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0009006	prolonged estrous cycle	"increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0009011	prolonged diestrus	"increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0009019	abnormal metestrus	"any anomaly or aberrant timing of the phase of the estrous cycle which follows estrus when mature eggs move through the oviducts and into the uterus; the vulva is no longer bloated, and the vagina is now closed" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0009114	decreased pancreatic beta cell mass	"reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Ghr^tm1.1Dlr/Ghr^tm1.1Dlr,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * DBA
MP:0009118	increased white fat cell size	"increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0009172	small pancreatic islets	"decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0009285	increased gonadal fat pad weight	"greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0009286	increased abdominal fat pad weight	"greater than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0009289	decreased epididymal fat pad weight		Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ghr^tm1.1Jero/Ghr^tm1.1Jero Genetic Background: B6.129X1-Ghr^tm1.1Jero
MP:0009293	decreased inguinal fat pad weight		Show Allelic Composition: Ghr^tm1.1Jero/Ghr^tm1.1Jero Genetic Background: B6.129X1-Ghr^tm1.1Jero
MP:0009294	increased interscapular fat pad weight		Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0009298	increased mesenteric fat pad weight		Show Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0009304	increased retroperitoneal fat pad weight		Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0009356	decreased liver triglyceride level	"lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1.1Masp/Ghr^tm1.1Masp,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA
MP:0009425	increased soleus weight	"increase in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0009431	decreased fetal weight	"reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0009674	decreased birth weight	"reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm2Mwat/Ghr^tm2Mwat Genetic Background: involves: 129X1/SvJ * C57BL Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0010090	increased circulating creatine kinase level	"an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0010934	increased subcutaneous adipose tissue amount	"increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi},Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6N
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0011820	decreased pancreatic beta cell proliferation	"reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]	Show Allelic Composition: Ghr^tm1.1Dlr/Ghr^tm1.1Dlr,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * DBA
MP:0011939	increased food intake	"increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0013618	decreased areal bone mineral density	"reduction of the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978]	Show Allelic Composition: Ghr^tm1Jjk/Ghr^tm1Jjk Genetic Background: involves: 129P2/OlaHsd * BALB/c

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020919	P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*	/ complex / reaction
ENSMUSG00000004043	P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*	/ complex / reaction
ENSMUSG00000004266	Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*	/ reaction / complex
ENSMUSG00000038037	Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*	/ complex / reaction
ENSMUSG00000027540	Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*	/ complex / reaction
ENSMUSG00000042228	Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*	/ complex / reaction
ENSMUSG00000024789	Jak2 / Janus kinase 2 / O60674*	/ reaction / complex
ENSMUSG00000004040	Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*	/ complex / reaction
ENSMUSG00000055737	Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*	/ complex / reaction
ENSMUSG00000020713	Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...	/ reaction / complex
ENSMUSG00000053113	Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*	/ reaction / complex
ENSMUSG00000052593	Adam17 / Q9Z0F8 / Disintegrin and metalloproteinase domain-containing protein 17 / P78536* / ADAM metallopeptidase domain 17*	/ reaction

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