ENSMUSG00000027540


Mus musculus

Features
Gene ID: ENSMUSG00000027540
  
Biological name :Ptpn1
  
Synonyms : P35821 / protein tyrosine phosphatase, non-receptor type 1 / Ptpn1
  
Possible biological names infered from orthology : P18031
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 167932057
Gene end: 167979385
  
Corresponding Affymetrix probe sets: 10478897 (MoGene1.0st)   1417068_a_at (Mouse Genome 430 2.0 Array)   1438670_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029053
NCBI entrez gene - 19246     See in Manteia.
MGI - MGI:97805
RefSeq - XM_006498981
RefSeq - NM_011201
RefSeq Peptide - NP_035331
swissprot - P35821
swissprot - Q3TZW9
Ensembl - ENSMUSG00000027540
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn1ENSDARG00000007923Danio rerio
 PTPN1ENSGALG00000008010Gallus gallus
 PTPN1ENSG00000196396Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptpn2 / Q06180 / Tyrosine-protein phosphatase non-receptor type 2 / P17706* / protein tyrosine phosphatase, non-receptor type 2*ENSMUSG0000002453952
P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*ENSMUSG0000002877125
Ptprb / B2RU80 / protein tyrosine phosphatase, receptor type, B / P23467*ENSMUSG0000002015425
Ptpn9 / O35239 / protein tyrosine phosphatase, non-receptor type 9 / P43378*ENSMUSG0000003229025
P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*ENSMUSG0000002784324
Ptprh / E9Q0N2 / Receptor-type tyrosine-protein phosphatase H / Q9HD43* / protein tyrosine phosphatase, receptor type H*ENSMUSG0000003542924
Ptpn18 / Q61152 / protein tyrosine phosphatase, non-receptor type 18 / Q99952*ENSMUSG0000002612624
Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*ENSMUSG0000002531423
Ptpro / E9Q612 / Receptor-type tyrosine-protein phosphatase O / Q16827* / protein tyrosine phosphatase, receptor type O*ENSMUSG0000003022323
O55082 / Ptpn20 / Tyrosine-protein phosphatase non-receptor type 20 / Q4JDL3* / protein tyrosine phosphatase, non-receptor type 20*ENSMUSG0000002194021
Ptprq / P0C5E4 / Phosphatidylinositol phosphatase PTPRQ / protein tyrosine phosphatase, receptor type Q*ENSMUSG0000003591620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012265  Protein-tyrosine phosphatase, non-receptor type-1/2
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation ISO
 biological_processGO:0007257 activation of JUN kinase activity IMP
 biological_processGO:0008286 insulin receptor signaling pathway IMP
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030100 regulation of endocytosis IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IGI
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0033157 regulation of intracellular protein transport IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035791 platelet-derived growth factor receptor-beta signaling pathway IMP
 biological_processGO:0036498 IRE1-mediated unfolded protein response IMP
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IGI
 biological_processGO:1902202 regulation of hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903898 negative regulation of PERK-mediated unfolded protein response IEA
 biological_processGO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IGI
 biological_processGO:2000646 positive regulation of receptor catabolic process IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum NAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0097443 sorting endosome IDA
 cellular_componentGO:0098554 cytoplasmic side of endoplasmic reticulum membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Negative regulation of MET activity
PTK6 Down-Regulation
Regulation of IFNA signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000683 decreased percent water in carcass "less than the normal total amount of water retained in the body measured post mortem" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Itga6tm1Egl/Itga6tm1Egl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * CD-1)

Allelic Composition: Ptpn1tm1Bbk/Ptpn1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itga6tm1Egl/Itga6tm1Egl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * CD-1)

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itga6tm1Egl/Itga6tm1Egl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * CD-1)

Allelic Composition: Ptpn1tm1Bbk/Ptpn1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn1tm1Bbk/Ptpn1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004129 abnormal respiratory quotient "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005451 abnormal body composition "anomalous relative amounts of various components of the body, such as percent body fat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn1Gt(OST378842)Lex/Ptpn1Gt(OST378842)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn1tm1Bpk/Ptpn1+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn1tm1Bpk/Ptpn1+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn1tm1Bbk/Ptpn1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009295 decreased interscapular fat pad weight 
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011016 increased core body temperature "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022967 Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*  / reaction
 ENSMUSG00000022971 O35664 / Ifnar2 / interferon (alpha and beta) receptor 2 / P48551* / AP000295.1* / interferon alpha and beta receptor subunit 2*  / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / reaction
 ENSMUSG00000055737 Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*  / reaction / complex
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / reaction
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / reaction
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / reaction / complex
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / reaction
 ENSMUSG00000048806 Ifnb1 / P01575 / interferon beta 1, fibroblast / P01574* / interferon beta 1*  / reaction
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / reaction
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / reaction
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr