ENSMUSG00000035916


Mus musculus

Features
Gene ID: ENSMUSG00000035916
  
Biological name :Ptprq
  
Synonyms : P0C5E4 / Phosphatidylinositol phosphatase PTPRQ / Ptprq
  
Possible biological names infered from orthology : protein tyrosine phosphatase, receptor type Q
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D1
Gene start: 107517049
Gene end: 107720051
  
Corresponding Affymetrix probe sets: 10372235 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000058572
NCBI entrez gene - 237523     See in Manteia.
MGI - MGI:1096349
RefSeq - XM_017313939
RefSeq - NM_001081432
RefSeq - XM_006513635
RefSeq - XM_017313938
RefSeq Peptide - NP_001074901
swissprot - P0C5E4
Ensembl - ENSMUSG00000035916
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprqENSDARG00000008849Danio rerio
 PTPRQENSGALG00000010935Gallus gallus
 PTPRQENSG00000139304Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprb / B2RU80 / protein tyrosine phosphatase, receptor type, B / P23467*ENSMUSG0000002015418
Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*ENSMUSG0000002531414
Ptpro / E9Q612 / Receptor-type tyrosine-protein phosphatase O / Q16827* / protein tyrosine phosphatase, receptor type O*ENSMUSG0000003022311
Ptprh / E9Q0N2 / Receptor-type tyrosine-protein phosphatase H / Q9HD43* / protein tyrosine phosphatase, receptor type H*ENSMUSG0000003542911
Ptpn9 / O35239 / protein tyrosine phosphatase, non-receptor type 9 / P43378*ENSMUSG000000322906
O55082 / Ptpn20 / Tyrosine-protein phosphatase non-receptor type 20 / Q4JDL3* / protein tyrosine phosphatase, non-receptor type 20*ENSMUSG000000219405
Ptpn18 / Q61152 / protein tyrosine phosphatase, non-receptor type 18 / Q99952*ENSMUSG000000261264
Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*ENSMUSG000000275404
Ptpn2 / Q06180 / Tyrosine-protein phosphatase non-receptor type 2 / P17706* / protein tyrosine phosphatase, non-receptor type 2*ENSMUSG000000245394
P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*ENSMUSG000000278434
P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*ENSMUSG000000287714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0045598 regulation of fat cell differentiation ISO
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IMP
 biological_processGO:0060116 vestibular receptor cell morphogenesis IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032421 stereocilium bundle IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004431 abnormal hair cell mechanoelectric transduction "anomalous conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004515 abnormal vestibular hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004531 short outer hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004533 fused inner hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004534 decreased inner hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004585 absent vestibular hair bundle shaft connectors "absence of the inter-stereocilial links that connect the shafts of neighboring stereocilia in vestibular hair bundles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pld4mpc96H/Pld4mpc96H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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