ENSMUSG00000009376


Mus musculus

Features
Gene ID: ENSMUSG00000009376
  
Biological name :Met
  
Synonyms : Met / MET proto-oncogene, receptor tyrosine kinase
  
Possible biological names infered from orthology : P08581
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A2
Gene start: 17463800
Gene end: 17573980
  
Corresponding Affymetrix probe sets: 10536505 (MoGene1.0st)   1422990_at (Mouse Genome 430 2.0 Array)   1434447_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121923
Ensembl peptide - ENSMUSP00000117856
Ensembl peptide - ENSMUSP00000118755
Ensembl peptide - ENSMUSP00000079324
Ensembl peptide - ENSMUSP00000111102
Ensembl peptide - ENSMUSP00000111103
NCBI entrez gene - 17295     See in Manteia.
MGI - MGI:96969
RefSeq - XM_011241043
RefSeq - NM_008591
RefSeq - XM_006505002
RefSeq - XM_011241042
RefSeq Peptide - NP_032617
swissprot - D3YVY2
swissprot - F6X333
swissprot - F8VQL0
swissprot - F6RCC5
Ensembl - ENSMUSG00000009376
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 metENSDARG00000070903Danio rerio
 METENSGALG00000036883Gallus gallus
 METENSG00000105976Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mst1r / Q62190 / macrophage stimulating 1 receptor (c-met-related tyrosine kinase) / Q04912* / macrophage stimulating 1 receptor*ENSMUSG0000003258434
Mertk / Q60805 / Tyrosine-protein kinase Mer / Q12866* / MER proto-oncogene, tyrosine kinase*ENSMUSG0000001436115
Tyro3 / P55144 / TYRO3 protein tyrosine kinase 3 / Q06418* / TYRO3 protein tyrosine kinase*ENSMUSG0000002729814
Axl / Q00993 / AXL receptor tyrosine kinase / P30530*ENSMUSG0000000260214
Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*ENSMUSG0000000638613
Tie1 / Q06806 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / P35590*ENSMUSG0000003319113
Ryk / Q01887 / Tyrosine-protein kinase RYK / receptor-like tyrosine kinase*ENSMUSG0000003254712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR016244  Tyrosine-protein kinase, HGF/MSP receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001886 endothelial cell morphogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051497 negative regulation of stress fiber assembly IEA
 biological_processGO:0061436 establishment of skin barrier IEA
 biological_processGO:0070495 negative regulation of thrombin-activated receptor signaling pathway IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death IEA
 biological_processGO:1905098 negative regulation of guanyl-nucleotide exchange factor activity IEA
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis IEA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Sema4D mediated inhibition of cell attachment and migration
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
NTRK2 activates RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

Allelic Composition: Mettm2Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Wnt3tm1Amc/Wnt3tm2Amc,Tg(Rarb-cre)1Mrc/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Mettm2Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mettm1Kln/Mettm1Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm,Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Mettm1Kln/Mettm1Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mettm1Kln/Mettm1Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: ICR

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Wnt3tm1Amc/Wnt3tm2Amc,Tg(Rarb-cre)1Mrc/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000860 abnormal primary somatosensory cortex morphology "any malformation or absence of the area of the postcentral gyrus and central sulcus that is involved in somatic sensation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Mettm1Cpo/Mettm1Sst,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Mettm1Ics/Mettm1Sst,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm1Cpo/Mettm1Sst,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001051 abnormal somatic motor system morphology 
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Allelic Composition: Mettm1Kln/Mettm1Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Mettm1Cpo/Mettm1Sst,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wnt3tm1Amc/Wnt3tm2Amc,Tg(Rarb-cre)1Mrc/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Mettm1Cpo/Mettm1Sst,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mettm2Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-HBEGF*L148S*P149T)70Rin/0
Genetic Background: CB17/lcr-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Mettm2Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

Allelic Composition: Mettm2Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm3Gvw/Mettm3Gvw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mettm2Gvw/Mettm2Gvw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm3Gvw/Mettm3Gvw
Genetic Background: involves: 129 * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm3Cpo/Mettm3Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: ICR

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Msx2tm1Rilm/Msx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S4/SvEvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

Allelic Composition: Mettm2Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0003090 abnormal muscle progenitor cell migration "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mettm1Kln/Mettm1Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: ICR

 MP:0003326 liver failure "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003359 hypaxial muscle hypoplasia "reduced cell number in the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm,Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: ICR

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mettm1Kln/Mettm1Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Mettm1Ics/Mettm1Sst,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Mettm2Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm3Gvw/Mettm3Gvw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: ICR

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

Allelic Composition: Mettm2Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm3Gvw/Mettm3Gvw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004136 abnormal tongue muscle morphology "anomalous structure or development of the muscular portion of the tongue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004170 abnormal orbitofrontal cortex morphology "any malformation or absence of the region of the cerebral cortex covering the basal surface of the frontal lobes; this region normally controls emotion and decision making" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004197 abnormal fetal growth/weight/body size "limited or accelerated growth or development apparent during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mettm1Kln/Mettm1Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mettm1Kln/Mettm1Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Mettm1Ics/Mettm1Sst,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mettm2Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mettm1Kln/Mettm1Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0004846 absent skeletal muscle "absence of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Kittm1Shta/Kit+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mettm2Cbm/Mettm2.1Cbm,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0008986 abnormal liver parenchyma morphology "any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

Allelic Composition: Mettm2Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mettm2Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt3tm1Amc/Wnt3tm2Amc,Tg(Rarb-cre)1Mrc/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Gab1tm3Wbm/Gab1tm3Wbm,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt3tm1Amc/Wnt3tm2Amc,Tg(Rarb-cre)1Mrc/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mettm1Sst/Mettm1Sst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010267 decreased lung tumor incidence "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtf1Thyls-BALB/c/Mtf1Thyls-MSM
Genetic Background: involves: BALB/c * MSM

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Wnt3tm1Amc/Wnt3tm2Amc,Tg(Rarb-cre)1Mrc/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Mettm2Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mettm2Kln/Mettm2Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

Allelic Composition: Mettm2Gvw/Mettm2Gvw
Genetic Background: involves: 129 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mettm3Gvw/Mettm3Gvw
Genetic Background: involves: 129 * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mettm1Kln/Mettm1Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Nf2tm2Gvn/Nf2+
Genetic Background: Not Specified

 MP:0011883 absent diaphragm "absence of the thin musculomebranous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [MGI:Colin_McKerlie]
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Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012043 increased myoepithelioma incidence "greater than the expected occurrence of a benign tumor of myoepithelial cells, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
Show

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0012251 abnormal diaphragm development "malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [MGI:anna]
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Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

Allelic Composition: Mettm2Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J

 MP:0020344 abnormal susceptibility to injury induced morbidity/mortality "differences from the expected moribund state caused by trauma, especially that by physical means" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Mettm1Sst/Mettm1Sst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030208 abnormal intrinsic tongue muscle morphology "any structural anomaly of any of the four paired muscles that originate and insert within the tongue, running along its length; these muscles alter the shape of the tongue by lengthening and shortening it, curling and uncurling its apex and edges, and flattening and rounding its surface; they include the superior longitudinal muscle, the inferior longitudinal muscle, the vertical muscle, and the transverse muscle" [https://en.wikipedia.org/wiki/Tongue, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Muscles-of-tongue, MGI:anna]
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Allelic Composition: Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000017607 Tns4 / Q8BZ33 / Tensin-4 / Q8IZW8*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000020422 Tns3 / Q5SSZ5 / Tensin-3 / Q68CZ2*  / reaction / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000020740 Gga3 / Q8BMI3 / ADP-ribosylation factor-binding protein GGA3 / Q9NZ52* / golgi associated, gamma adaptin ear containing, ARF binding protein 3*  / complex
 ENSMUSG00000021451 O09126 / Sema4d / Semaphorin-4D / Q92854*  / reaction / complex
 ENSMUSG00000024539 Ptpn2 / Q06180 / Tyrosine-protein phosphatase non-receptor type 2 / P17706* / protein tyrosine phosphatase, non-receptor type 2*  / reaction
 ENSMUSG00000026718 Stam / P70297 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / Q92783* / signal transducing adaptor molecule*  / reaction / complex
 ENSMUSG00000037415 Ranbp10 / RAN binding protein 10 / Q6VN20*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction / complex
 ENSMUSG00000030029 Lrig1 / P70193 / Leucine-rich repeats and immunoglobulin-like domains protein 1 / Q96JA1* / leucine rich repeats and immunoglobulin like domains 1*  / complex / reaction
 ENSMUSG00000035638 Muc20 / Q8BUE7 / Mucin-20 / Q8N307* / mucin 20, cell surface associated*  / complex / reaction
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000028552 Eps15 / P42567 / Epidermal growth factor receptor substrate 15 / P42566* / epidermal growth factor receptor pathway substrate 15*  / complex / reaction
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000027363 Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*  / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000053646 Plxnb1 / Q8CJH3 / plexin B1 / O43157*  / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000044147 Arf6 / P62331 / ADP-ribosylation factor 6 / P62330*  / complex
 ENSMUSG00000040990 Q8R550 / Sh3kbp1 / SH3 domain-containing kinase-binding protein 1 / Q96B97*  / reaction / complex
 ENSMUSG00000058230 Q91YM2 / Arhgap35 / Rho GTPase activating protein 35 / Q9NRY4*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000055371 Stam2 / O88811 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / signal transducing adaptor molecule 2*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000025314 Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*  / reaction
 ENSMUSG00000038546 P69566 / Ranbp9 / Ran-binding protein 9 / Q96S59*  / reaction / complex






 

1 s.

 
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