ENSMUSG00000026718


Mus musculus

Features
Gene ID: ENSMUSG00000026718
  
Biological name :Stam
  
Synonyms : P70297 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / Stam
  
Possible biological names infered from orthology : Q92783 / signal transducing adaptor molecule
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A1
Gene start: 14074098
Gene end: 14149634
  
Corresponding Affymetrix probe sets: 10469335 (MoGene1.0st)   1416861_at (Mouse Genome 430 2.0 Array)   1416862_at (Mouse Genome 430 2.0 Array)   1457828_at (Mouse Genome 430 2.0 Array)   1459427_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121228
Ensembl peptide - ENSMUSP00000141207
Ensembl peptide - ENSMUSP00000028050
Ensembl peptide - ENSMUSP00000100025
NCBI entrez gene - 20844     See in Manteia.
MGI - MGI:1329014
RefSeq - NM_011484
RefSeq - XM_017316829
RefSeq Peptide - NP_035614
swissprot - Q3TQ49
swissprot - Q3UGN9
swissprot - P70297
swissprot - A0A0A6YVP6
swissprot - A2ARJ0
Ensembl - ENSMUSG00000026718
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stamENSDARG00000002127Danio rerio
 STAMENSGALG00000035287Gallus gallus
 STAMENSG00000136738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stam2 / O88811 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / signal transducing adaptor molecule 2*ENSMUSG0000005537151


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002014  VHS domain
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS
 IPR035657  STAM1, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:1903543 positive regulation of exosomal secretion IEA
 biological_processGO:1903551 regulation of extracellular exosome assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0033565 ESCRT-0 complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Metalloprotease DUBs
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0003415 priapism "prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0009971 decreased hippocampus pyramidal cell number "decreased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014402 Q61187 / Tsg101 / tumor susceptibility gene 101 / Q99816* / tumor susceptibility 101*  / reaction
 ENSMUSG00000040990 Q8R550 / Sh3kbp1 / SH3 domain-containing kinase-binding protein 1 / Q96B97*  / reaction / complex
 ENSMUSG00000006906 Q9CQ26 / Stambp / STAM-binding protein / O95630*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSMUSG00000028552 Eps15 / P42567 / Epidermal growth factor receptor substrate 15 / P42566* / epidermal growth factor receptor pathway substrate 15*  / complex
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction / complex
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / complex / reaction
 ENSMUSG00000066278 Q8R0J7 / Vps37b / vacuolar protein sorting 37B / Q9H9H4* / VPS37B, ESCRT-I subunit*  / reaction
 ENSMUSG00000031813 Mvb12a / Q78HU3 / Multivesicular body subunit 12A / Q96EY5*  / reaction
 ENSMUSG00000038740 Mvb12b / Q6KAU4 / Multivesicular body subunit 12B / Q9H7P6*  / reaction
 ENSMUSG00000043614 Q810I0 / Vps37d / vacuolar protein sorting 37D / Q86XT2* / VPS37D, ESCRT-I subunit*  / reaction
 ENSMUSG00000028437 Ubap1 / Q8BH48 / ubiquitin-associated protein 1 / Q9NZ09*  / reaction
 ENSMUSG00000048832 Q8R105 / Vps37c / vacuolar protein sorting 37C / A5D8V6* / VPS37C, ESCRT-I subunit*  / reaction
 ENSMUSG00000115987 Vps28 / Q9D1C8 / vacuolar protein sorting 28 / Q9UK41* / VPS28, ESCRT-I subunit*  / reaction
 ENSMUSG00000031600 Q8CHS8 / Vps37a / vacuolar protein sorting 37A / Q8NEZ2* / VPS37A, ESCRT-I subunit*  / reaction






 

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