ENSMUSG00000115987


Mus musculus

Features
Gene ID: ENSMUSG00000115987
  
Biological name :Vps28
  
Synonyms : Q9D1C8 / vacuolar protein sorting 28 / Vps28
  
Possible biological names infered from orthology : Q9UK41 / VPS28, ESCRT-I subunit
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 76622087
Gene end: 76626086
  
Corresponding Affymetrix probe sets: 10430020 (MoGene1.0st)   1448447_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077856
Ensembl peptide - ENSMUSP00000155847
NCBI entrez gene - 66914     See in Manteia.
MGI - MGI:1914164
RefSeq - NM_001305668
RefSeq - NM_025842
RefSeq Peptide - NP_001292597
RefSeq Peptide - NP_080118
swissprot - Q9D1C8
Ensembl - ENSMUSG00000115987
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps28ENSDARG00000103203Danio rerio
 VPS28ENSG00000160948Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007143  Vacuolar protein sorting-associated Vps28
 IPR017898  Vacuolar protein sorting-associated, VPS28, N-terminal
 IPR017899  Vacuolar protein sorting-associated, VPS28, C-terminal
 IPR037202  ESCRT assembly domain
 IPR037206  VPS28, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0032509 endosome transport via multivesicular body sorting pathway IEA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
 biological_processGO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:2000397 positive regulation of ubiquitin-dependent endocytosis IEA
 cellular_componentGO:0000813 ESCRT I complex ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 molecular_functionGO:0043130 ubiquitin binding IEA


Pathways (from Reactome)
Pathway description
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014402 Q61187 / Tsg101 / tumor susceptibility gene 101 / Q99816* / tumor susceptibility 101*  / complex
 ENSMUSG00000066278 Q8R0J7 / Vps37b / vacuolar protein sorting 37B / Q9H9H4* / VPS37B, ESCRT-I subunit*  / complex
 ENSMUSG00000031813 Mvb12a / Q78HU3 / Multivesicular body subunit 12A / Q96EY5*  / complex
 ENSMUSG00000038740 Mvb12b / Q6KAU4 / Multivesicular body subunit 12B / Q9H7P6*  / complex
 ENSMUSG00000043614 Q810I0 / Vps37d / vacuolar protein sorting 37D / Q86XT2* / VPS37D, ESCRT-I subunit*  / complex
 ENSMUSG00000028437 Ubap1 / Q8BH48 / ubiquitin-associated protein 1 / Q9NZ09*  / complex
 ENSMUSG00000048832 Q8R105 / Vps37c / vacuolar protein sorting 37C / A5D8V6* / VPS37C, ESCRT-I subunit*  / complex
 ENSMUSG00000006058 Snf8 / Q9CZ28 / Mus musculus SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) (Snf8), transcript variant 2, mRNA. / Q96H20* / SNF8, ESCRT-II complex subunit*  / reaction
 ENSMUSG00000031479 Vps36 / Q91XD6 / vacuolar protein sorting 36 / Q86VN1* / vacuolar protein sorting 36 homolog*  / reaction
 ENSMUSG00000026718 Stam / P70297 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / Q92783* / signal transducing adaptor molecule*  / reaction
 ENSMUSG00000055371 Stam2 / O88811 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / signal transducing adaptor molecule 2*  / reaction
 ENSMUSG00000078656 Vps25 / Q9CQ80 / vacuolar protein sorting 25 / Q9BRG1* / vacuolar protein sorting 25 homolog*  / reaction
 ENSMUSG00000031600 Q8CHS8 / Vps37a / vacuolar protein sorting 37A / Q8NEZ2* / VPS37A, ESCRT-I subunit*  / complex






 

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