ENSG00000160948


Homo sapiens

Features
Gene ID: ENSG00000160948
  
Biological name :VPS28
  
Synonyms : Q9UK41 / VPS28 / VPS28, ESCRT-I subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.3
Gene start: 144423601
Gene end: 144428563
  
Corresponding Affymetrix probe sets: 218679_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432395
Ensembl peptide - ENSP00000436102
Ensembl peptide - ENSP00000434556
Ensembl peptide - ENSP00000434393
Ensembl peptide - ENSP00000434064
Ensembl peptide - ENSP00000433228
Ensembl peptide - ENSP00000292510
Ensembl peptide - ENSP00000366565
Ensembl peptide - ENSP00000431243
NCBI entrez gene - 51160     See in Manteia.
OMIM - 611952
RefSeq - XM_005272323
RefSeq - XM_011517100
RefSeq - XM_011517099
RefSeq - NM_016208
RefSeq - NM_183057
RefSeq - XM_017013529
RefSeq - XM_005272324
RefSeq - XM_005272325
RefSeq Peptide - NP_898880
RefSeq Peptide - NP_057292
swissprot - Q9UK41
swissprot - Q548N1
swissprot - E9PR04
swissprot - E9PLM9
swissprot - E9PM90
swissprot - E9PQR7
Ensembl - ENSG00000160948
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps28ENSDARG00000103203Danio rerio
 Vps28ENSMUSG00000115987Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007143  Vacuolar protein sorting-associated Vps28
 IPR017898  Vacuolar protein sorting-associated, VPS28, N-terminal
 IPR017899  Vacuolar protein sorting-associated, VPS28, C-terminal
 IPR037202  ESCRT assembly domain
 IPR037206  VPS28, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0019058 viral life cycle TAS
 biological_processGO:0031397 negative regulation of protein ubiquitination IDA
 biological_processGO:0032509 endosome transport via multivesicular body sorting pathway IEA
 biological_processGO:0036258 multivesicular body assembly TAS
 biological_processGO:0039702 viral budding via host ESCRT complex TAS
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
 biological_processGO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0075733 intracellular transport of virus TAS
 biological_processGO:2000397 positive regulation of ubiquitin-dependent endocytosis IMP
 cellular_componentGO:0000813 ESCRT I complex TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043130 ubiquitin binding IDA


Pathways (from Reactome)
Pathway description
Budding and maturation of HIV virion
Membrane binding and targetting of GAG proteins
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131475 VPS25 / Q9BRG1 / vacuolar protein sorting 25 homolog  / reaction
 ENSG00000074319 Q99816 / TSG101 / tumor susceptibility 101  / complex
 ENSG00000115145 STAM2 / O75886 / signal transducing adaptor molecule 2  / reaction
 ENSG00000159210 SNF8 / Q96H20 / SNF8, ESCRT-II complex subunit  / reaction
 ENSG00000139722 Q9H9H4 / VPS37B / VPS37B, ESCRT-I subunit  / complex
 ENSG00000141971 MVB12A / Q96EY5 / multivesicular body subunit 12A  / complex
 ENSG00000165006 UBAP1 / Q9NZ09 / ubiquitin associated protein 1  / complex
 ENSG00000155975 Q8NEZ2 / VPS37A / VPS37A, ESCRT-I subunit  / complex
 ENSG00000196814 MVB12B / Q9H7P6 / multivesicular body subunit 12B  / complex
 ENSG00000176428 Q86XT2 / VPS37D / VPS37D, ESCRT-I subunit  / complex
 ENSG00000167987 A5D8V6 / VPS37C / VPS37C, ESCRT-I subunit  / complex
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / reaction
 ENSG00000136100 VPS36 / Q86VN1 / vacuolar protein sorting 36 homolog  / reaction
 ENSG00000136738 STAM / Q92783 / signal transducing adaptor molecule  / reaction






 

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