ENSG00000136100


Homo sapiens

Features
Gene ID: ENSG00000136100
  
Biological name :VPS36
  
Synonyms : Q86VN1 / vacuolar protein sorting 36 homolog / VPS36
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q14.3
Gene start: 52412602
Gene end: 52450628
  
Corresponding Affymetrix probe sets: 222478_at (Human Genome U133 Plus 2.0 Array)   240086_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000367299
Ensembl peptide - ENSP00000484968
NCBI entrez gene - 51028     See in Manteia.
OMIM - 610903
RefSeq - NM_001282169
RefSeq - NM_001282168
RefSeq - NM_016075
RefSeq Peptide - NP_001269097
RefSeq Peptide - NP_001269098
RefSeq Peptide - NP_057159
swissprot - Q86VN1
Ensembl - ENSG00000136100
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps36ENSDARG00000057021Danio rerio
 VPS36ENSGALG00000017026Gallus gallus
 Vps36ENSMUSG00000031479Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011993  PH-like domain superfamily
 IPR021648  Vacuolar protein sorting protein 36, GLUE domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0032509 endosome transport via multivesicular body sorting pathway IEA
 biological_processGO:0036258 multivesicular body assembly TAS
 biological_processGO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
 cellular_componentGO:0000814 ESCRT II complex TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IEA
 molecular_functionGO:0043130 ubiquitin binding IMP


Pathways (from Reactome)
Pathway description
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131475 VPS25 / Q9BRG1 / vacuolar protein sorting 25 homolog  / complex
 ENSG00000159210 SNF8 / Q96H20 / SNF8, ESCRT-II complex subunit  / complex
 ENSG00000139722 Q9H9H4 / VPS37B / VPS37B, ESCRT-I subunit  / reaction
 ENSG00000196814 MVB12B / Q9H7P6 / multivesicular body subunit 12B  / reaction
 ENSG00000155975 Q8NEZ2 / VPS37A / VPS37A, ESCRT-I subunit  / reaction
 ENSG00000176428 Q86XT2 / VPS37D / VPS37D, ESCRT-I subunit  / reaction
 ENSG00000167987 A5D8V6 / VPS37C / VPS37C, ESCRT-I subunit  / reaction
 ENSG00000074319 Q99816 / TSG101 / tumor susceptibility 101  / reaction
 ENSG00000160948 VPS28 / Q9UK41 / VPS28, ESCRT-I subunit  / reaction
 ENSG00000165006 UBAP1 / Q9NZ09 / ubiquitin associated protein 1  / reaction
 ENSG00000141971 MVB12A / Q96EY5 / multivesicular body subunit 12A  / reaction






 

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