ENSG00000159210


Homo sapiens

Features
Gene ID: ENSG00000159210
  
Biological name :SNF8
  
Synonyms : Q96H20 / SNF8 / SNF8, ESCRT-II complex subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.32
Gene start: 48929316
Gene end: 48945117
  
Corresponding Affymetrix probe sets: 218391_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427328
Ensembl peptide - ENSP00000422701
Ensembl peptide - ENSP00000460001
Ensembl peptide - ENSP00000467548
Ensembl peptide - ENSP00000460981
Ensembl peptide - ENSP00000290330
Ensembl peptide - ENSP00000421380
Ensembl peptide - ENSP00000421390
Ensembl peptide - ENSP00000421956
NCBI entrez gene - 11267     See in Manteia.
OMIM - 610904
RefSeq - XM_017024075
RefSeq - NM_001317192
RefSeq - NM_001317193
RefSeq - NM_001317194
RefSeq - NM_007241
RefSeq Peptide - NP_001304123
RefSeq Peptide - NP_009172
RefSeq Peptide - NP_001304121
RefSeq Peptide - NP_001304122
swissprot - D6RJ86
swissprot - D6RFY6
swissprot - H0Y8S5
swissprot - I3L457
swissprot - I3L2X5
swissprot - K7EPV2
swissprot - Q96H20
swissprot - D6RBI1
Ensembl - ENSG00000159210
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snf8ENSDARG00000058076Danio rerio
 SNF8ENSGALG00000001309Gallus gallus
 Snf8ENSMUSG00000006058Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016689  ESCRT-2 complex, Snf8
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010797 regulation of multivesicular body size involved in endosome transport IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0032456 endocytic recycling IMP
 biological_processGO:0036258 multivesicular body assembly TAS
 biological_processGO:0042176 regulation of protein catabolic process IMP
 biological_processGO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
 biological_processGO:0045022 early endosome to late endosome transport IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0061635 regulation of protein complex stability IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071985 multivesicular body sorting pathway IEA
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 biological_processGO:1903772 regulation of viral budding via host ESCRT complex IMP
 cellular_componentGO:0000814 ESCRT II complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0016247 channel regulator activity IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131475 VPS25 / Q9BRG1 / vacuolar protein sorting 25 homolog  / complex
 ENSG00000155975 Q8NEZ2 / VPS37A / VPS37A, ESCRT-I subunit  / reaction
 ENSG00000196814 MVB12B / Q9H7P6 / multivesicular body subunit 12B  / reaction
 ENSG00000141971 MVB12A / Q96EY5 / multivesicular body subunit 12A  / reaction
 ENSG00000139722 Q9H9H4 / VPS37B / VPS37B, ESCRT-I subunit  / reaction
 ENSG00000160948 VPS28 / Q9UK41 / VPS28, ESCRT-I subunit  / reaction
 ENSG00000165006 UBAP1 / Q9NZ09 / ubiquitin associated protein 1  / reaction
 ENSG00000167987 A5D8V6 / VPS37C / VPS37C, ESCRT-I subunit  / reaction
 ENSG00000176428 Q86XT2 / VPS37D / VPS37D, ESCRT-I subunit  / reaction
 ENSG00000074319 Q99816 / TSG101 / tumor susceptibility 101  / reaction
 ENSG00000136100 VPS36 / Q86VN1 / vacuolar protein sorting 36 homolog  / complex






 

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