ENSG00000131475


Homo sapiens

Features
Gene ID: ENSG00000131475
  
Biological name :VPS25
  
Synonyms : Q9BRG1 / vacuolar protein sorting 25 homolog / VPS25
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.2
Gene start: 42773436
Gene end: 42779599
  
Corresponding Affymetrix probe sets: 224608_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467225
Ensembl peptide - ENSP00000253794
Ensembl peptide - ENSP00000465798
Ensembl peptide - ENSP00000466909
NCBI entrez gene - 84313     See in Manteia.
OMIM - 610907
RefSeq - XM_017025224
RefSeq - NM_032353
RefSeq Peptide - NP_115729
swissprot - K7ENE3
swissprot - K7EP45
swissprot - A0A024R1X3
swissprot - Q9BRG1
swissprot - K7EKV4
Ensembl - ENSG00000131475
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps25ENSDARG00000059079Danio rerio
 VPS25ENSGALG00000034262Gallus gallus
 Vps25ENSMUSG00000078656Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008570  ESCRT-II complex, Vps25 subunit
 IPR014041  ESCRT-II complex, Vps25 subunit, N-terminal winged helix
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0036258 multivesicular body assembly TAS
 biological_processGO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
 biological_processGO:0071985 multivesicular body sorting pathway IEA
 cellular_componentGO:0000814 ESCRT II complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005198 structural molecule activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000155975 Q8NEZ2 / VPS37A / VPS37A, ESCRT-I subunit  / reaction
 ENSG00000196814 MVB12B / Q9H7P6 / multivesicular body subunit 12B  / reaction
 ENSG00000141971 MVB12A / Q96EY5 / multivesicular body subunit 12A  / reaction
 ENSG00000139722 Q9H9H4 / VPS37B / VPS37B, ESCRT-I subunit  / reaction
 ENSG00000159210 SNF8 / Q96H20 / SNF8, ESCRT-II complex subunit  / complex
 ENSG00000131475 VPS25 / Q9BRG1 / vacuolar protein sorting 25 homolog  / complex
 ENSG00000160948 VPS28 / Q9UK41 / VPS28, ESCRT-I subunit  / reaction
 ENSG00000165006 UBAP1 / Q9NZ09 / ubiquitin associated protein 1  / reaction
 ENSG00000167987 A5D8V6 / VPS37C / VPS37C, ESCRT-I subunit  / reaction
 ENSG00000176428 Q86XT2 / VPS37D / VPS37D, ESCRT-I subunit  / reaction
 ENSG00000074319 Q99816 / TSG101 / tumor susceptibility 101  / reaction
 ENSG00000136100 VPS36 / Q86VN1 / vacuolar protein sorting 36 homolog  / complex






 

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