ENSG00000196814


Homo sapiens

Features
Gene ID: ENSG00000196814
  
Biological name :MVB12B
  
Synonyms : multivesicular body subunit 12B / MVB12B / Q9H7P6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q33.3
Gene start: 126326849
Gene end: 126507041
  
Corresponding Affymetrix probe sets: 1554065_at (Human Genome U133 Plus 2.0 Array)   221687_s_at (Human Genome U133 Plus 2.0 Array)   221828_s_at (Human Genome U133 Plus 2.0 Array)   52975_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000485994
Ensembl peptide - ENSP00000354772
Ensembl peptide - ENSP00000384751
NCBI entrez gene - 89853     See in Manteia.
RefSeq - XM_017015278
RefSeq - NM_033446
RefSeq - XM_005252297
RefSeq - XM_017015275
RefSeq - XM_017015276
RefSeq - XM_017015277
RefSeq - NM_001011703
RefSeq Peptide - NP_001011703
RefSeq Peptide - NP_258257
swissprot - F8W922
swissprot - Q9H7P6
swissprot - A0A024R8B8
Ensembl - ENSG00000196814
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mvb12baENSDARG00000091619Danio rerio
 MVB12BENSGALG00000000950Gallus gallus
 Mvb12bENSMUSG00000038740Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MVB12A / Q96EY5 / multivesicular body subunit 12AENSG0000014197128


Protein motifs (from Interpro)
Interpro ID Name
 IPR018798  Multivesicular body subunit 12
 IPR023340  UMA domain
 IPR023341  MABP domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0019058 viral life cycle TAS
 biological_processGO:0019075 virus maturation IMP
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IC
 biological_processGO:0048524 positive regulation of viral process IMP
 biological_processGO:0075733 intracellular transport of virus TAS
 cellular_componentGO:0000813 ESCRT I complex IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IMP


Pathways (from Reactome)
Pathway description
Budding and maturation of HIV virion
Membrane binding and targetting of GAG proteins
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131475 VPS25 / Q9BRG1 / vacuolar protein sorting 25 homolog  / reaction
 ENSG00000074319 Q99816 / TSG101 / tumor susceptibility 101  / complex
 ENSG00000115145 STAM2 / O75886 / signal transducing adaptor molecule 2  / reaction
 ENSG00000159210 SNF8 / Q96H20 / SNF8, ESCRT-II complex subunit  / reaction
 ENSG00000167987 A5D8V6 / VPS37C / VPS37C, ESCRT-I subunit  / complex
 ENSG00000139722 Q9H9H4 / VPS37B / VPS37B, ESCRT-I subunit  / complex
 ENSG00000160948 VPS28 / Q9UK41 / VPS28, ESCRT-I subunit  / complex
 ENSG00000155975 Q8NEZ2 / VPS37A / VPS37A, ESCRT-I subunit  / complex
 ENSG00000176428 Q86XT2 / VPS37D / VPS37D, ESCRT-I subunit  / complex
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / reaction
 ENSG00000136100 VPS36 / Q86VN1 / vacuolar protein sorting 36 homolog  / reaction
 ENSG00000136738 STAM / Q92783 / signal transducing adaptor molecule  / reaction






 

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