ENSG00000115145


Homo sapiens

Features
Gene ID: ENSG00000115145
  
Biological name :STAM2
  
Synonyms : O75886 / signal transducing adaptor molecule 2 / STAM2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q23.3
Gene start: 152116801
Gene end: 152175992
  
Corresponding Affymetrix probe sets: 208194_s_at (Human Genome U133 Plus 2.0 Array)   209649_at (Human Genome U133 Plus 2.0 Array)   215044_s_at (Human Genome U133 Plus 2.0 Array)   228254_at (Human Genome U133 Plus 2.0 Array)   242569_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263904
NCBI entrez gene - 10254     See in Manteia.
OMIM - 606244
RefSeq - NM_005843
RefSeq Peptide - NP_005834
swissprot - O75886
Ensembl - ENSG00000115145
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stam2ENSDARG00000005318Danio rerio
 STAM2ENSGALG00000012513Gallus gallus
 Stam2ENSMUSG00000055371Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STAM / Q92783 / signal transducing adaptor moleculeENSG0000013673856


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002014  VHS domain
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS
 IPR035675  STAM2, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0036258 multivesicular body assembly TAS
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0033565 ESCRT-0 complex TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
EGFR downregulation
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000074319 Q99816 / TSG101 / tumor susceptibility 101  / reaction
 ENSG00000167987 A5D8V6 / VPS37C / VPS37C, ESCRT-I subunit  / reaction
 ENSG00000176428 Q86XT2 / VPS37D / VPS37D, ESCRT-I subunit  / reaction
 ENSG00000138592 USP8 / P40818 / ubiquitin specific peptidase 8  / complex
 ENSG00000165006 UBAP1 / Q9NZ09 / ubiquitin associated protein 1  / reaction
 ENSG00000160948 VPS28 / Q9UK41 / VPS28, ESCRT-I subunit  / reaction
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / complex
 ENSG00000141971 MVB12A / Q96EY5 / multivesicular body subunit 12A  / reaction
 ENSG00000085832 EPS15 / P42566 / epidermal growth factor receptor pathway substrate 15  / complex
 ENSG00000196814 MVB12B / Q9H7P6 / multivesicular body subunit 12B  / reaction
 ENSG00000155975 Q8NEZ2 / VPS37A / VPS37A, ESCRT-I subunit  / reaction
 ENSG00000139722 Q9H9H4 / VPS37B / VPS37B, ESCRT-I subunit  / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000147010 Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1  / reaction / complex
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / complex / reaction






 

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