ENSG00000074319


Homo sapiens

Features
Gene ID: ENSG00000074319
  
Biological name :TSG101
  
Synonyms : Q99816 / TSG101 / tumor susceptibility 101
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.1
Gene start: 18468336
Gene end: 18527232
  
Corresponding Affymetrix probe sets: 201758_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000251968
Ensembl peptide - ENSP00000438471
Ensembl peptide - ENSP00000463213
Ensembl peptide - ENSP00000464386
NCBI entrez gene - 7251     See in Manteia.
OMIM - 601387
RefSeq - XM_005253108
RefSeq - NM_006292
RefSeq Peptide - NP_006283
swissprot - J3QRU6
swissprot - F5H442
swissprot - Q99816
swissprot - J3QKS4
Ensembl - ENSG00000074319
  
Related genetic diseases (OMIM): 114480 - Breast cancer, somatic, 114480
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tsg101aENSDARG00000040854Danio rerio
 tsg101bENSDARG00000011897Danio rerio
 TSG101ENSGALG00000006312Gallus gallus
 Q61187ENSMUSG00000014402Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008883  Ubiquitin E2 variant, N-terminal
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR017916  Steadiness box (SB) domain
 IPR037202  ESCRT assembly domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006858 extracellular transport IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0019058 viral life cycle TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0036258 multivesicular body assembly TAS
 biological_processGO:0039702 viral budding via host ESCRT complex TAS
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IDA
 biological_processGO:0043405 regulation of MAP kinase activity IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0046755 viral budding IMP
 biological_processGO:0048524 positive regulation of viral process IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0075733 intracellular transport of virus TAS
 biological_processGO:0097352 autophagosome maturation TAS
 biological_processGO:1902188 positive regulation of viral release from host cell IMP
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 biological_processGO:1903551 regulation of extracellular exosome assembly IMP
 biological_processGO:1903772 regulation of viral budding via host ESCRT complex IMP
 biological_processGO:1903774 positive regulation of viral budding via host ESCRT complex IMP
 biological_processGO:1990182 exosomal secretion IEA
 biological_processGO:2000397 positive regulation of ubiquitin-dependent endocytosis IEA
 cellular_componentGO:0000813 ESCRT I complex TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IMP
 cellular_componentGO:0005771 multivesicular body TAS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043130 ubiquitin binding TAS
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0046790 virion binding IDA
 molecular_functionGO:0048306 calcium-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
Budding and maturation of HIV virion
Membrane binding and targetting of GAG proteins
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0001425 Heterogeneous 
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 HP:0003002 Breast cancer 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131475 VPS25 / Q9BRG1 / vacuolar protein sorting 25 homolog  / reaction
 ENSG00000176428 Q86XT2 / VPS37D / VPS37D, ESCRT-I subunit  / complex
 ENSG00000167987 A5D8V6 / VPS37C / VPS37C, ESCRT-I subunit  / complex
 ENSG00000155975 Q8NEZ2 / VPS37A / VPS37A, ESCRT-I subunit  / complex
 ENSG00000139722 Q9H9H4 / VPS37B / VPS37B, ESCRT-I subunit  / complex
 ENSG00000141971 MVB12A / Q96EY5 / multivesicular body subunit 12A  / complex
 ENSG00000196814 MVB12B / Q9H7P6 / multivesicular body subunit 12B  / complex
 ENSG00000165006 UBAP1 / Q9NZ09 / ubiquitin associated protein 1  / complex
 ENSG00000160948 VPS28 / Q9UK41 / VPS28, ESCRT-I subunit  / complex
 ENSG00000115145 STAM2 / O75886 / signal transducing adaptor molecule 2  / reaction
 ENSG00000159210 SNF8 / Q96H20 / SNF8, ESCRT-II complex subunit  / reaction
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / reaction
 ENSG00000136100 VPS36 / Q86VN1 / vacuolar protein sorting 36 homolog  / reaction
 ENSG00000136738 STAM / Q92783 / signal transducing adaptor molecule  / reaction






 

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