ENSMUSG00000014402


Mus musculus

Features
Gene ID: ENSMUSG00000014402
  
Biological name :Tsg101
  
Synonyms : Q61187 / Tsg101 / tumor susceptibility gene 101
  
Possible biological names infered from orthology : Q99816 / tumor susceptibility 101
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 46888949
Gene end: 46919969
  
Corresponding Affymetrix probe sets: 10424411 (MoGene1.0st)   10563643 (MoGene1.0st)   1417004_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014546
Ensembl peptide - ENSMUSP00000147749
Ensembl peptide - ENSMUSP00000147748
Ensembl peptide - ENSMUSP00000147701
Ensembl peptide - ENSMUSP00000121314
Ensembl peptide - ENSMUSP00000120856
NCBI entrez gene - 22088     See in Manteia.
MGI - MGI:106581
RefSeq - XM_006540790
RefSeq - NM_021884
RefSeq - XM_006540788
RefSeq - XM_006540789
RefSeq Peptide - NP_068684
swissprot - D3Z2V5
swissprot - Q3UCW0
swissprot - Q61187
swissprot - A0A1B0GS10
swissprot - A0A1B0GS09
swissprot - D3Z0S9
swissprot - A0A1B0GRX2
Ensembl - ENSMUSG00000014402
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tsg101aENSDARG00000040854Danio rerio
 tsg101bENSDARG00000011897Danio rerio
 TSG101ENSGALG00000006312Gallus gallus
 Q99816ENSG00000074319Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008883  Ubiquitin E2 variant, N-terminal
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR017916  Steadiness box (SB) domain
 IPR037202  ESCRT assembly domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IDA
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006858 extracellular transport ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030154 cell differentiation IDA
 biological_processGO:0030216 keratinocyte differentiation IDA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
 biological_processGO:0043405 regulation of MAP kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0046755 viral budding IMP
 biological_processGO:0048524 positive regulation of viral process IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1902188 positive regulation of viral release from host cell IEA
 biological_processGO:1903543 positive regulation of exosomal secretion IEA
 biological_processGO:1903551 regulation of extracellular exosome assembly IEA
 biological_processGO:1903772 regulation of viral budding via host ESCRT complex ISO
 biological_processGO:1903774 positive regulation of viral budding via host ESCRT complex ISO
 biological_processGO:1990182 exosomal secretion IMP
 biological_processGO:2000397 positive regulation of ubiquitin-dependent endocytosis IMP
 cellular_componentGO:0000813 ESCRT I complex NAS
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046790 virion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0004759 decreased mitotic index "decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adcyap1r1tm1Aba/Adcyap1r1tm1Aba
Genetic Background: involves: C57BL/6

Allelic Composition: Tsg101tm1Kuw/Tsg101tm1Kuw,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Adcyap1r1tm1.2Gsc/Adcyap1r1tm1.2Gsc,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)

 MP:0011187 abnormal parietal endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [PMID:19201946]
Show

Allelic Composition: Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078656 Vps25 / Q9CQ80 / vacuolar protein sorting 25 / Q9BRG1* / vacuolar protein sorting 25 homolog*  / reaction
 ENSMUSG00000028437 Ubap1 / Q8BH48 / ubiquitin-associated protein 1 / Q9NZ09*  / complex
 ENSMUSG00000043614 Q810I0 / Vps37d / vacuolar protein sorting 37D / Q86XT2* / VPS37D, ESCRT-I subunit*  / complex
 ENSMUSG00000031813 Mvb12a / Q78HU3 / Multivesicular body subunit 12A / Q96EY5*  / complex
 ENSMUSG00000038740 Mvb12b / Q6KAU4 / Multivesicular body subunit 12B / Q9H7P6*  / complex
 ENSMUSG00000115987 Vps28 / Q9D1C8 / vacuolar protein sorting 28 / Q9UK41* / VPS28, ESCRT-I subunit*  / complex
 ENSMUSG00000031600 Q8CHS8 / Vps37a / vacuolar protein sorting 37A / Q8NEZ2* / VPS37A, ESCRT-I subunit*  / complex
 ENSMUSG00000026718 Stam / P70297 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / Q92783* / signal transducing adaptor molecule*  / reaction
 ENSMUSG00000066278 Q8R0J7 / Vps37b / vacuolar protein sorting 37B / Q9H9H4* / VPS37B, ESCRT-I subunit*  / complex
 ENSMUSG00000031479 Vps36 / Q91XD6 / vacuolar protein sorting 36 / Q86VN1* / vacuolar protein sorting 36 homolog*  / reaction
 ENSMUSG00000048832 Q8R105 / Vps37c / vacuolar protein sorting 37C / A5D8V6* / VPS37C, ESCRT-I subunit*  / complex
 ENSMUSG00000055371 Stam2 / O88811 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / signal transducing adaptor molecule 2*  / reaction
 ENSMUSG00000006058 Snf8 / Q9CZ28 / Mus musculus SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) (Snf8), transcript variant 2, mRNA. / Q96H20* / SNF8, ESCRT-II complex subunit*  / reaction






 

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