ENSG00000185359


Homo sapiens

Features
Gene ID: ENSG00000185359
  
Biological name :HGS
  
Synonyms : hepatocyte growth factor-regulated tyrosine kinase substrate / HGS / O14964
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q25.3
Gene start: 81683326
Gene end: 81703138
  
Corresponding Affymetrix probe sets: 210428_s_at (Human Genome U133 Plus 2.0 Array)   232627_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000460130
Ensembl peptide - ENSP00000459685
Ensembl peptide - ENSP00000460165
Ensembl peptide - ENSP00000331201
Ensembl peptide - ENSP00000458603
Ensembl peptide - ENSP00000458775
Ensembl peptide - ENSP00000458789
Ensembl peptide - ENSP00000458987
NCBI entrez gene - 9146     See in Manteia.
OMIM - 604375
RefSeq - XM_017025298
RefSeq - NM_004712
RefSeq - XM_011525463
RefSeq - XM_017025297
RefSeq Peptide - NP_004703
swissprot - I3L2H4
swissprot - I3L326
swissprot - I3L346
swissprot - A0A0S2Z4R4
swissprot - O14964
swissprot - I3L165
swissprot - I3L1E3
swissprot - I3L1P5
swissprot - I3L1F1
Ensembl - ENSG00000185359
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hgsENSDARG00000020960Danio rerio
 HGSENSGALG00000007224Gallus gallus
 HgsENSMUSG00000116045Mus musculus
 HgsENSMUSG00000025793Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANKFY1 / Q9P2R3 / ankyrin repeat and FYVE domain containing 1ENSG0000018572217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR002014  VHS domain
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017073  Ubiquitin binding protein, Hrs/VPS27
 IPR017455  Zinc finger, FYVE-related
 IPR024641  Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006622 protein targeting to lysosome IMP
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0010324 membrane invagination IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport NAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0036258 multivesicular body assembly TAS
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0042176 regulation of protein catabolic process TAS
 biological_processGO:0043405 regulation of MAP kinase activity IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IDA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0072657 protein localization to membrane IMP
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032585 multivesicular body membrane IEA
 cellular_componentGO:0033565 ESCRT-0 complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Lysosome Vesicle Biogenesis
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000115145 STAM2 / O75886 / signal transducing adaptor molecule 2  / complex
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / reaction / complex
 ENSG00000196814 MVB12B / Q9H7P6 / multivesicular body subunit 12B  / reaction
 ENSG00000085832 EPS15 / P42566 / epidermal growth factor receptor pathway substrate 15  / complex
 ENSG00000074319 Q99816 / TSG101 / tumor susceptibility 101  / reaction
 ENSG00000176428 Q86XT2 / VPS37D / VPS37D, ESCRT-I subunit  / reaction
 ENSG00000167987 A5D8V6 / VPS37C / VPS37C, ESCRT-I subunit  / reaction
 ENSG00000130724 CHMP2A / O43633 / charged multivesicular body protein 2A  / complex / reaction
 ENSG00000138592 USP8 / P40818 / ubiquitin specific peptidase 8  / complex
 ENSG00000165006 UBAP1 / Q9NZ09 / ubiquitin associated protein 1  / reaction
 ENSG00000213983 AP1G2 / O75843 / adaptor related protein complex 1 gamma 2 subunit  / reaction / complex
 ENSG00000155975 Q8NEZ2 / VPS37A / VPS37A, ESCRT-I subunit  / reaction
 ENSG00000141971 MVB12A / Q96EY5 / multivesicular body subunit 12A  / reaction
 ENSG00000160948 VPS28 / Q9UK41 / VPS28, ESCRT-I subunit  / reaction
 ENSG00000139722 Q9H9H4 / VPS37B / VPS37B, ESCRT-I subunit  / reaction
 ENSG00000147010 Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1  / complex / reaction
 ENSG00000136738 STAM / Q92783 / signal transducing adaptor molecule  / complex
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / complex / reaction






 

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