9146


Homo sapiens (NCBI)
regulationproteinmembranebindinggrowthfactorreceptorsignalingpathwayendosomelysosomemultivesicularbodyearlytargetingsignaltransductioncellproliferationinvaginationgeneexpressionplatelet-derivedendosomaltransportmacroautophagyangiogenesisvascularendothelialassembly

Features
Gene ID: 9146
  
Biological name :
  
Synonyms : hepatocyte growth factor-regulated tyrosine kinase substrate / HGS / HRS
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 210428_s_at (Human Genome U133 Plus 2.0 Array)   232627_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034601963
RefSeq - 1034601965
RefSeq - 1370472583
RefSeq - 1370472585
RefSeq - 4758528
RefSeq - 767996449
RefSeq - NC_000017.11
RefSeq - NP_004703.1
RefSeq - XP_011523765.1
RefSeq - XP_016880786.1
RefSeq - XP_016880787.1
RefSeq - XP_024306792.1
RefSeq - XP_024306793.1
RefSeq - NM_004712.4
RefSeq - XM_024451025.1
RefSeq - XM_011525463.2
RefSeq - XM_017025297.1
RefSeq - XM_017025298.1
RefSeq - XM_024451024.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000185359 to get all the annotations available for this gene.


Gene Ontology (GO)
macromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimuluscellular component organizationorganic substance metabolic processcatabolic processcellular metabolic processprocess utilizing autophagic mechanismanatomical structure developmentresponse to chemicalcellular component biogenesisnitrogen compound metabolic processprimary metabolic processregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimuluscellular component organizationorganic substance metabolic processcatabolic processcellular metabolic processprocess utilizing autophagic mechanismanatomical structure developmentresponse to chemicalcellular component biogenesisnitrogen compound metabolic processprimary metabolic processregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimuluscellular component organizationorganic substance metabolic processcatabolic processcellular metabolic processprocess utilizing autophagic mechanismanatomical structure developmentresponse to chemicalcellular component biogenesisnitrogen compound metabolic processprimary metabolic processregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimuluscellular component organizationorganic substance metabolic processcatabolic processcellular metabolic processprocess utilizing autophagic mechanismanatomical structure developmentresponse to chemicalcellular component biogenesisnitrogen compound metabolic processprimary metabolic processregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimuluscellular component organizationorganic substance metabolic processcatabolic processcellular metabolic processprocess utilizing autophagic mechanismanatomical structure developmentresponse to chemicalcellular component biogenesisnitrogen compound metabolic processprimary metabolic processregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimuluscellular component organizationorganic substance metabolic processcatabolic processcellular metabolic processprocess utilizing autophagic mechanismanatomical structure developmentresponse to chemicalcellular component biogenesisnitrogen compound metabolic processprimary metabolic processregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimuluscellular component organizationorganic substance metabolic processcatabolic processcellular metabolic processprocess utilizing autophagic mechanismanatomical structure developmentresponse to chemicalcellular component biogenesisnitrogen compound metabolic processprimary metabolic processregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimuluscellular component organizationorganic substance metabolic processcatabolic processcellular metabolic processprocess utilizing autophagic mechanismanatomical structure developmentresponse to chemicalcellular component biogenesisnitrogen compound metabolic processprimary metabolic processregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimuluscellular component organizationorganic substance metabolic processcatabolic processcellular metabolic processprocess utilizing autophagic mechanismanatomical structure developmentresponse to chemicalcellular component biogenesisnitrogen compound metabolic processprimary metabolic processregulation of molecular functionmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimuluscellular component organizationorganic substance metabolic processcatabolic processcellular metabolic processprocess utilizing autophagic mechanismanatomical structure developmentresponse to chemicalcellular component biogenesisnitrogen compound metabolic processprimary metabolic processregulation of molecular functionmacromolmacromolecule localizationestablisestablishment of localizationcellularcellular localizationcell comcell communicationcellularcellular response to stimuluscellularcellular component organizationorganic organic substance metabolic processcatabolicatabolic processcellularcellular metabolic processprocess process utilizing autophagic mechanismanatomicanatomical structure developmentresponseresponse to chemicalcellularcellular component biogenesisnitrogennitrogen compound metabolic processprimary primary metabolic processregulatiregulation of molecular function
protein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingprotein bindingion bindingion binding
cellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complexextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0006622 protein targeting to lysosome IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0010324 membrane invagination IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0036258 multivesicular body assembly TAS
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0042176 regulation of protein catabolic process TAS
 biological_processGO:0043405 regulation of MAP kinase activity IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IDA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0072657 protein localization to membrane IMP
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032585 multivesicular body membrane IEA
 cellular_componentGO:0033565 ESCRT-0 complex TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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