ENSG00000130724


Homo sapiens

Features
Gene ID: ENSG00000130724
  
Biological name :CHMP2A
  
Synonyms : charged multivesicular body protein 2A / CHMP2A / O43633
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.43
Gene start: 58551566
Gene end: 58555124
  
Corresponding Affymetrix probe sets: 202121_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472097
Ensembl peptide - ENSP00000471961
Ensembl peptide - ENSP00000472680
Ensembl peptide - ENSP00000310440
Ensembl peptide - ENSP00000469240
Ensembl peptide - ENSP00000469453
NCBI entrez gene - 27243     See in Manteia.
OMIM - 610893
RefSeq - XM_005258747
RefSeq - NM_014453
RefSeq - NM_198426
RefSeq - XM_005258746
RefSeq Peptide - NP_940818
RefSeq Peptide - NP_055268
swissprot - M0R1T5
swissprot - O43633
swissprot - M0QXX8
swissprot - M0R1L7
swissprot - A0A024R4S0
Ensembl - ENSG00000130724
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chmp2aENSDARG00000053979Danio rerio
 Chmp2aENSMUSG00000033916Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHMP2B / Q9UQN3 / charged multivesicular body protein 2BENSG0000008393731


Protein motifs (from Interpro)
Interpro ID Name
 IPR005024  Snf7 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000920 cell separation after cytokinesis IMP
 biological_processGO:0006997 nucleus organization IMP
 biological_processGO:0007034 vacuolar transport IEA
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0010324 membrane invagination IMP
 biological_processGO:0010458 exit from mitosis IMP
 biological_processGO:0010824 regulation of centrosome duplication IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0019058 viral life cycle TAS
 biological_processGO:0031468 nuclear envelope reassembly IMP
 biological_processGO:0036258 multivesicular body assembly TAS
 biological_processGO:0039702 viral budding via host ESCRT complex IMP
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0050792 regulation of viral process IMP
 biological_processGO:0051258 protein polymerization IMP
 biological_processGO:0051260 protein homooligomerization IMP
 biological_processGO:0051291 protein heterooligomerization IMP
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:1901673 regulation of mitotic spindle assembly IMP
 biological_processGO:1902188 positive regulation of viral release from host cell IMP
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 biological_processGO:1903723 negative regulation of centriole elongation IMP
 biological_processGO:1904903 ESCRT III complex disassembly NAS
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000815 ESCRT III complex IDA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IMP
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031210 phosphatidylcholine binding IMP


Pathways (from Reactome)
Pathway description
Budding and maturation of HIV virion
Macroautophagy
Lysosome Vesicle Biogenesis
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000213983 AP1G2 / O75843 / adaptor related protein complex 1 gamma 2 subunit  / reaction / complex
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / complex / reaction






 

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