ENSMUSG00000025793


Mus musculus

Features
Gene ID: ENSMUSG00000025793
  
Biological name :Hgs
  
Synonyms : Hgs
  
Possible biological names infered from orthology : hepatocyte growth factor-regulated tyrosine kinase substrate / O14964
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 120467635
Gene end: 120483979
  
Corresponding Affymetrix probe sets: 10383365 (MoGene1.0st)   1416540_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101811
Ensembl peptide - ENSMUSP00000119396
Ensembl peptide - ENSMUSP00000115037
Ensembl peptide - ENSMUSP00000101809
MGI - MGI:104681
swissprot - B1ATZ1
swissprot - B1ATZ0
swissprot - F6VV02
swissprot - B1ATY9
Ensembl - ENSMUSG00000025793
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hgsENSDARG00000020960Danio rerio
 HGSENSGALG00000007224Gallus gallus
 HGSENSG00000185359Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hgs / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate*ENSMUSG0000011604578
Ankfy1 / Q810B6 / Rabankyrin-5 / Q9P2R3* / ankyrin repeat and FYVE domain containing 1*ENSMUSG0000002079017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR002014  VHS domain
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017073  Ubiquitin binding protein, Hrs/VPS27
 IPR017455  Zinc finger, FYVE-related
 IPR024641  Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032585 multivesicular body membrane IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Lysosome Vesicle Biogenesis
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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