ENSDARG00000020960


Danio rerio

Features
Gene ID: ENSDARG00000020960
  
Biological name :hgs
  
Synonyms : hepatocyte growth factor-regulated tyrosine kinase substrate / hgs
  
Possible biological names infered from orthology : hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 / O14964
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 50076793
Gene end: 50118140
  
Corresponding Affymetrix probe sets: Dr.12079.1.A1_at (Zebrafish Array)   Dr.13744.1.A1_at (Zebrafish Array)   Dr.18448.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000121032
NCBI entrez gene - 334175     See in Manteia.
RefSeq - XM_021469616
RefSeq - XM_021469618
RefSeq - XM_021469622
RefSeq - XM_021469625
RefSeq Peptide - NP_956162
swissprot - E9QCS7
ZFIN ID - ZDB-GENE-030131-6107
Ensembl - ENSDARG00000020960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HGSENSGALG00000007224Gallus gallus
 HGSENSG00000185359Homo sapiens
 HgsENSMUSG00000116045Mus musculus
 HgsENSMUSG00000025793Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ankfy1 / ankyrin repeat and FYVE domain containing 1 / Q810B6* / Q9P2R3* / Rabankyrin-5 *ENSDARG0000006101316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR002014  VHS domain
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017073  Ubiquitin binding protein, Hrs/VPS27
 IPR017455  Zinc finger, FYVE-related
 IPR024641  Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Lysosome Vesicle Biogenesis
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005318 stam2 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / O88811* / signal transducing adaptor molecule 2*  / complex
 ENSDARG00000078216 eps15 / epidermal growth factor receptor pathway substrate 15 / P42566* / P42567* / Epidermal growth factor receptor substrate 15 *  / complex
 ENSDARG00000075853 sh3kbp1 / SH3-domain kinase binding protein 1 / Q8R550* / Q96B97* / SH3 domain containing kinase binding protein 1*  / complex / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction / complex
 ENSDARG00000011897 tsg101b / tumor susceptibility 101b / Q99816* / TSG101* / Q61187* / tumor susceptibility 101* / tumor susceptibility gene 101*  / reaction
 ENSDARG00000031836 vps37c / vacuolar protein sorting 37 homolog C (S. cerevisiae) / Q8R105* / A5D8V6* / VPS37C, ESCRT-I subunit* / vacuolar protein sorting 37C*  / reaction
 ENSDARG00000039319 vps37b / vacuolar protein sorting 37 homolog B (S. cerevisiae) / Q8R0J7* / Q9H9H4* / VPS37B, ESCRT-I subunit* / vacuolar protein sorting 37B*  / reaction
 ENSDARG00000103203 vps28 / vacuolar protein sorting 28 (yeast) / Q9D1C8* / Q9UK41* / VPS28, ESCRT-I subunit* / vacuolar protein sorting 28*  / reaction
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000097055 si:ch211-284f22.3 / Q86XT2* / Q810I0* / VPS37D* / VPS37D, ESCRT-I subunit* / vacuolar protein sorting 37D*  / reaction
 ENSDARG00000058746 ubap1 / ubiquitin associated protein 1 / Q8BH48* / Q9NZ09*  / reaction
 ENSDARG00000002127 stam / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / P70297* / Q92783* / signal transducing adaptor molecule*  / complex
 ENSDARG00000063719 usp8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*  / complex
 ENSDARG00000054337 ap1g2 / adaptor-related protein complex 1, gamma 2 subunit / O75843*  / complex / reaction






 

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