ENSDARG00000078216


Danio rerio

Features
Gene ID: ENSDARG00000078216
  
Biological name :eps15
  
Synonyms : epidermal growth factor receptor pathway substrate 15 / eps15
  
Possible biological names infered from orthology : Epidermal growth factor receptor substrate 15 / P42566 / P42567
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 16514830
Gene end: 16559241
  
Corresponding Affymetrix probe sets: Dr.248.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000089463
Ensembl peptide - ENSDARP00000108750
NCBI entrez gene - 795505     See in Manteia.
swissprot - F1QIJ6
swissprot - F1QV21
ZFIN ID - ZDB-GENE-081104-264
Ensembl - ENSDARG00000078216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EPS15ENSGALG00000010543Gallus gallus
 EPS15ENSG00000085832Homo sapiens
 Eps15ENSMUSG00000028552Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eps15l1a / epidermal growth factor receptor pathway substrate 15-like 1a / Q9UBC2* / Q60902* / EPS15L1* / Epidermal growth factor receptor substrate 15-like 1 * / epidermal growth factor re...ENSDARG0000004267039
CABZ01066725.1 / Q9UBC2* / EPS15L1* / epidermal growth factor receptor pathway substrate 15 like 1*ENSDARG0000010070022
itsn1 / intersectin 1 (SH3 domain protein) / Q15811* / Q9Z0R4* / intersectin 1*ENSDARG0000000008618
itsn2a / intersectin 2a / ITSN2* / Q9NZM3* / intersectin 2*ENSDARG0000000016117
itsn2b / intersectin 2b / ITSN2* / Q9NZM3* / intersectin 2*ENSDARG0000005497317
reps1 / RALBP1 associated Eps domain containing 1 / O54916* / Q96D71* / RalBP1-associated Eps domain-containing protein 1 *ENSDARG0000000287712
ehd3 / EH-domain containing 3 / Q9NZN3*ENSDARG000000078698
ehd4 / EH-domain containing 4 / Q9EQP2* / Q9H223* / EH domain-containing protein 4 *ENSDARG000000543028
ehd1a / EH-domain containing 1a / EHD1* / Q9WVK4* / Q9H4M9* / EH domain containing 1* / EH domain-containing protein 1 *ENSDARG000000988537
ehd2b / EH-domain containing 2b / EHD2* / Q9NZN4* / Q8BH64* / EH domain containing 2* / EH domain-containing protein 2 *ENSDARG000000403627
reps2 / RALBP1 associated Eps domain containing 2 / Q8NFH8*ENSDARG000000767687
ehd1b / EH-domain containing 1b / EHD1* / Q9WVK4* / Q9H4M9* / EH domain containing 1* / EH domain-containing protein 1 *ENSDARG000000147937
ehd2a / EH-domain containing 2a / EHD2* / Q9NZN4* / Q8BH64* / EH domain containing 2* / EH domain-containing protein 2 *ENSDARG000000351377
srl / sarcalumenin / Q86TD4*ENSDARG000001045875
CABZ01072309.1 / SRL* / Q86TD4* / sarcalumenin*ENSDARG000001129594
LO017845.1 / REPS2* / Q8NFH8* / RALBP1 associated Eps domain containing 2*ENSDARG000001150133


Protein motifs (from Interpro)
Interpro ID Name
 IPR000261  EH domain
 IPR002048  EF-hand domain
 IPR003903  Ubiquitin interacting motif
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005318 stam2 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / O88811* / signal transducing adaptor molecule 2*  / complex
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction / complex
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000075853 sh3kbp1 / SH3-domain kinase binding protein 1 / Q8R550* / Q96B97* / SH3 domain containing kinase binding protein 1*  / reaction / complex
 ENSDARG00000020960 hgs / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / complex
 ENSDARG00000076768 reps2 / RALBP1 associated Eps domain containing 2 / Q8NFH8*  / reaction / complex
 ENSDARG00000002127 stam / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / P70297* / Q92783* / signal transducing adaptor molecule*  / complex






 

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