ENSDARG00000000086


Danio rerio

Features
Gene ID: ENSDARG00000000086
  
Biological name :itsn1
  
Synonyms : intersectin 1 (SH3 domain protein) / itsn1
  
Possible biological names infered from orthology : intersectin 1 / Q15811 / Q9Z0R4
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 46999441
Gene end: 47089818
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000115952
Ensembl peptide - ENSDARP00000140669
NCBI entrez gene - 368504     See in Manteia.
RefSeq - NM_207182
RefSeq Peptide - NP_997065
swissprot - A8E7E7
swissprot - A0A0R4IWJ1
ZFIN ID - ZDB-GENE-030616-226
Ensembl - ENSDARG00000000086
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITSN1ENSGALG00000036677Gallus gallus
 ITSN1ENSG00000205726Homo sapiens
 Itsn1ENSMUSG00000022957Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itsn2a / intersectin 2a / ITSN2* / Q9NZM3* / intersectin 2*ENSDARG0000000016149
itsn2b / intersectin 2b / ITSN2* / Q9NZM3* / intersectin 2*ENSDARG0000005497347
eps15l1a / epidermal growth factor receptor pathway substrate 15-like 1a / Q9UBC2* / Q60902* / EPS15L1* / Epidermal growth factor receptor substrate 15-like 1 * / epidermal growth factor re...ENSDARG0000004267011
eps15 / epidermal growth factor receptor pathway substrate 15 / P42566* / P42567* / Epidermal growth factor receptor substrate 15 *ENSDARG0000007821611
reps1 / RALBP1 associated Eps domain containing 1 / O54916* / Q96D71* / RalBP1-associated Eps domain-containing protein 1 *ENSDARG000000028777
CABZ01066725.1 / Q9UBC2* / EPS15L1* / epidermal growth factor receptor pathway substrate 15 like 1*ENSDARG000001007007
ehd2b / EH-domain containing 2b / EHD2* / Q9NZN4* / Q8BH64* / EH domain containing 2* / EH domain-containing protein 2 *ENSDARG000000403625
ehd1a / EH-domain containing 1a / EHD1* / Q9WVK4* / Q9H4M9* / EH domain containing 1* / EH domain-containing protein 1 *ENSDARG000000988535
ehd1b / EH-domain containing 1b / EHD1* / Q9WVK4* / Q9H4M9* / EH domain containing 1* / EH domain-containing protein 1 *ENSDARG000000147935
ehd3 / EH-domain containing 3 / Q9NZN3*ENSDARG000000078695
reps2 / RALBP1 associated Eps domain containing 2 / Q8NFH8*ENSDARG000000767685
ehd4 / EH-domain containing 4 / Q9EQP2* / Q9H223* / EH domain-containing protein 4 *ENSDARG000000543025
ehd2a / EH-domain containing 2a / EHD2* / Q9NZN4* / Q8BH64* / EH domain containing 2* / EH domain-containing protein 2 *ENSDARG000000351374
srl / sarcalumenin / Q86TD4*ENSDARG000001045873
CABZ01072309.1 / SRL* / Q86TD4* / sarcalumenin*ENSDARG000001129592
LO017845.1 / REPS2* / Q8NFH8* / RALBP1 associated Eps domain containing 2*ENSDARG000001150130


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000219  Dbl homology (DH) domain
 IPR000261  EH domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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